{"product_id":"abcam-ab131256","title":"Abcam, ab131256, Anti-CD84 antibody [EPR8325]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CD84 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8325,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCD84 also known as SLAMF5 is a cell surface glycoprotein with a molecular weight of approximately 64 kDa. It belongs to the signaling lymphocyte activation molecule (SLAM) family. CD84 is expressed on various immune cells including B cells T cells dendritic cells monocytes and platelets. This protein plays a role in cell signaling facilitating interactions between immune cells by acting as a homophilic receptor.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCD84 contributes to the regulation of immune responses and intercellular communication. It is a part of the SLAM family which involves a signaling complex known as SLAM-associated protein (SAP) pathway. CD84 aids in the modulation of cell survival cytokine production and calcium mobilization thereby influencing immune cell function and maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nCD84 plays a role in key immune signaling pathways including the SAP signaling network and T-cell receptor pathways. CD84 interacts closely with SAP and other related proteins such as SLAM and 2B4 which help propagate T-cell activation signals and influence immune regulation. This position underlines CD84's engagement in regulating immune surveillance and homeostasis.\u003cbr\u003e\nCD84 has been implicated in autoimmune conditions and hematological malignancies. For instance it associates with systemic lupus erythematosus where altered expression may contribute to dysregulated immune responses. CD84 also plays a role in chronic lymphocytic leukemia correlating with disease progression and immune evasion. Its connection with proteins like SLAMF6 and SAP further highlights CD84's involvement in these pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850387148969,"sku":"ab131256","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab131256","provider":"Iright","version":"1.0","type":"link"}