{"product_id":"abcam-ab131702","title":"Abcam, ab131702, Recombinant Human UBTD2 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human UBTD2 protein is a Human Full Length protein, in the 1 to 234 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q8WUN7,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUBTD2 also known as Ubiquitin Domain Containing 2 is a protein that plays a role in cellular processes involving ubiquitination. It has a molecular mass of approximately 22 kDa. UBTD2 is widely expressed in human tissues with notable levels in the brain liver and heart. The protein contains a ubiquitin-like domain suggesting involvement in pathways related to protein degradation or signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUBTD2 regulates protein turnover by interacting with the ubiquitin-proteasome system impacting cellular stress responses. UBTD2 is part of a complex that includes other proteins such as E3 ubiquitin ligases which facilitate the tagging of proteins for degradation. This function impacts various pathways in response to cell damage or stress aiding in the maintenance of cellular health by removing misfolded or damaged proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of UBTD2 fits into processes such as the cell cycle and apoptosis regulation. In the ubiquitin-proteasome pathway UBTD2 collaborates with proteins like HECTD3 an E3 ubiquitin ligase to mediate the degradation of specific proteins involved in these pathways. Its role in these processes highlights its importance in maintaining cellular homeostasis and ensuring proper cell cycle progression.\u003cbr\u003e\nUBTD2 is linked with cancer and neurodegenerative diseases. Altered expression of UBTD2 has been observed in certain types of cancer suggesting it may influence tumor progression. Additionally its connection to neurodegenerative diseases points to its role in proteostasis failure often seen in disorders such as Alzheimer's disease. UBTD2 interacts with proteins like Tau which are known to accumulate abnormally in neurodegenerative conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844004663465,"sku":"ab131702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab131702","provider":"Iright","version":"1.0","type":"link"}