{"product_id":"abcam-ab131909","title":"Abcam, ab131909, Recombinant Human PRMT2\/HMT1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PRMT2\/HMT1 protein is a Human Full Length protein, in the 1 to 433 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P55345,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as PRMT2.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein Arginine Methyltransferase 2 (PRMT2) also known as HMT1 is a member of the protein arginine methyltransferase family. This enzyme carries out the transfer of methyl groups to arginine residues on target proteins influencing gene expression. PRMT2 has a molecular mass of about 59 kDa. It is detected widely in human tissues most notably in the liver heart and brain. This distribution indicates its involvement in a broad range of cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPRMT2 regulates various processes through its methylation activity. It functions as a coactivator particularly in the nuclear hormone receptor pathway. This protein is part of complexes that modify chromatin affecting gene transcription regulation. Through methylation of histones and other proteins PRMT2 influences cellular differentiation and proliferation. By modifying these key components PRMT2 controls important physiological functions within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nPRMT2 interacts closely with nuclear hormone receptor signaling and pathways associated with gene regulation. These connections make it particularly important in the estrogen receptor signaling pathway where PRMT2 acts in conjunction with other proteins like PRMT1. Additionally PRMT2 has roles in influencing the PI3K\/AKT pathway an important signaling pathway related to cell survival and metabolism.\u003cbr\u003e\nPRMT2 exhibits relevant associations with conditions like cancer and neurological disorders. In cancer altered PRMT2 expression can misregulate gene expression through disrupted methylation promoting tumorigenic processes. Its dysregulation also connects to inflammation and degenerative diseases in the nervous system often involving proteins like PRMT1 as collaborators in pathology development. Understanding these links with diseases can guide therapeutic approaches involving PRMT2 modulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843885453481,"sku":"ab131909","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab131909","provider":"Iright","version":"1.0","type":"link"}