{"product_id":"abcam-ab132822","title":"Abcam, ab132822, Recombinant Human Pellino-3 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Pellino-3 protein is a Human Full Length protein, in the 1 to 331 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q8N2H9,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as PELI3.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPellino-3 also called PEK3 functions as an important E3 ubiquitin ligase in multiple cellular processes. This protein with an approximate mass of 50 kDa promotes the ubiquitination of target proteins which can signal for their degradation or alter their activity. Pellino-3 displays expression in a variety of human tissues including immune cells where it supports immune responses. Researchers have extensively studied its role in intracellular signaling networks due to its ability to modify other proteins through ubiquitination.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Pellino-3 protein participates in the regulation of immune signaling pathways and is frequently associated with the Toll\/Interleukin-1 receptor (TIR) superfamily complex. It plays an important role in modulating the activity of TIRAP\/Mal and MyD88 two adaptors that are important for signaling through these pathways. By modifying signaling proteins in immune cells Pellino-3 helps control the overall immune response and inflammation levels within the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nPellino-3 integrates into critical immune regulatory pathways particularly the NF-κB and MAPK pathways. In the NF-κB pathway Pellino-3 ubiquitinates intermediates like TRAF6 which subsequently triggers downstream signaling leading to inflammation and immune responses. Interaction with proteins in the MAPK pathway shows how Pellino-3 can influence the cellular response to stress or pathogens. Robust regulation of these pathways maintains homeostasis and protects against excessive immune reactions.\u003cbr\u003e\nPellino-3 influences the development and progression of autoimmune diseases and inflammatory disorders. Elevated activity or expression of Pellino-3 links to conditions such as rheumatoid arthritis where dysregulated immune signaling occurs. The protein also interacts with other proteins like MyD88 in these disorders highlighting its potential as a therapeutic target. Understanding the role of Pellino-3 in these contexts may offer new strategies for managing immune-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843886043305,"sku":"ab132822","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab132822","provider":"Iright","version":"1.0","type":"link"}