{"product_id":"abcam-ab133160","title":"Abcam, ab133160, Anti-ARPC1A antibody","description":"\u003cp\u003eSize: 200µL\u003cbr\u003e\nGoat Polyclonal ARPC1A antibody. Suitable for WB and reacts with Rat, Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ARPC1A aa 350 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Goat,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ARPC1A aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92747,\u003cbr\u003e\nSpecificity:This antibody is expected to recognize both reported isoforms (NP_006400.2; NP_001177925.1). No cross-reactiviry expected with ARPC1B.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nARPC1A also known as Actin Related Protein 2\/3 Complex Subunit 1A is a component of the ARP2\/3 complex which plays a role in the regulation of actin filament assembly. It has a molecular mass of approximately 41 kDa. You can find ARPC1A expressed in various tissues with higher levels in muscle and neural tissues. The protein actively participates in actin cytoskeleton reorganization influencing cell shape and motility.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ARP2\/3 complex which includes ARPC1A facilitates the formation of branched actin networks. This function supports important cellular processes like endocytosis cell migration and cell-cell adhesion. As part of the multiprotein ARP2\/3 complex ARPC1A cooperates with other subunits to initiate and stimulate rapid actin polymerization providing a scaffold for cellular structure and transport pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nARPC1A participates actively in the Arp2\/3-mediated actin nucleation pathway as well as pathways involved in cell motility and morphogenesis. This protein works closely with members of the Wiskott-Aldrich syndrome protein (WASP) family which activate the ARP2\/3 complex. Additionally ARPC1A interacts within the Rho GTPase signaling pathways contributing to cytoskeletal rearrangements.\u003cbr\u003e\nMutations or dysregulation of ARPC1A can contribute to cancer progression and developmental disorders. Specifically its role in promoting actin assembly links ARPC1A to certain invasive and metastatic cancer behaviors. The ARPC1A connection to actin dynamics also associates it with focal segmental glomerulosclerosis when functioning improperly. In the context of these diseases ARPC1A influences the interaction with other proteins like cortactin which is involved in cell stability and integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854458278057,"sku":"ab133160","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab133160","provider":"Iright","version":"1.0","type":"link"}