{"product_id":"abcam-ab134616","title":"Abcam, ab134616, Recombinant Human PARVA protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human PARVA protein is a Human Full Length protein, in the 1 to 372 aa range, expressed in Escherichia coli, with \u0026gt;85%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;85% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9NVD7,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as Parvin alpha\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein PARVA also known as α-parvin is a 42 kDa protein expressed in various tissues including muscle and endothelial cells. PARVA acts mechanically as an adaptor protein playing an important role within focal adhesions. It interacts with structural and signaling molecules integrating signals from the extracellular matrix. Through such interactions it contributes to cellular adhesion and migration processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPARVA plays a role in cytoskeletal organization and cell shape regulation. As part of the integrin-linked kinase (ILK) complex it connects integrins at the cell surface with actin filaments in the cytoskeleton. This complex formation influences intracellular signaling pathways allowing cells to respond to mechanical stress and environmental signals. The dynamic restructuring of the actin cytoskeleton through PARVA is essential for cellular motility and morphogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nPARVA is an integral component of the PI3K-Akt signaling pathway and is also involved in the RhoA\/ROCK pathway. Within these pathways it collaborates with proteins like integrin-linked kinase (ILK) and PINCH to mediate cell survival proliferation and migration. These pathways are essential for various cellular responses positioning PARVA as a significant element in controlling cellular behavior in response to external stimuli.\u003cbr\u003e\nResearch reveals PARVA's involvement in cancer progression and cardiovascular diseases. In cancer aberrant PARVA function or expression can alter cell adhesion and motility contributing to metastasis. Collaborating proteins like ILK and PINCH become deregulated influencing pathways associated with tumor growth. In cardiovascular disorders PARVA's role in endothelial cell function impacts vascular integrity where its dysregulation can lead to conditions such as atherosclerosis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844005286057,"sku":"ab134616","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab134616","provider":"Iright","version":"1.0","type":"link"}