{"product_id":"abcam-ab135909","title":"Abcam, ab135909, Anti-AGPAT4 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal AGPAT4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human AGPAT4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human AGPAT4. The exact immunogen used to generate this antibody is proprietary information.Q9NRZ5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAGPAT4 also known as 1-acylglycerol-3-phosphate O-acyltransferase 4 plays a mechanical role in glycerolipid biosynthesis. It catalyzes the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA) by adding an acyl group. AGPAT4 has a mass of approximately 47 kDa. The highest expression of this enzyme occurs in tissues such as the liver kidney and brain indicating its importance in lipid metabolism in these areas.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n1-acylglycerol-3-phosphate O-acyltransferase enzymes like AGPAT4 are key in the synthesis of triacylglycerol and phospholipids components of cell membranes. AGPAT4 is not part of a larger complex but operates independently to perform its enzymatic function within the cell's lipid production pathways. This enzyme is essential for maintaining the balance of energy storage and membrane structure.\u003cbr\u003e\nPathways\u003cbr\u003e\nAGPAT4 is a critical component in the glycerolipid metabolism pathway affecting lipid biosynthesis and energy homeostasis. It links with proteins such as AGPAT1 sharing overlapping roles in the production of phosphatidic acid which serves as a precursor for other lipids. AGPAT4 also engages in the phosphatidylinositol signaling pathway influencing downstream cellular functions and signaling processes.\u003cbr\u003e\nAGPAT4 has connections to metabolic syndromes like obesity and liver disorders. Its altered function can disrupt normal lipid homeostasis leading to accumulation of lipids a characteristic of metabolic disease. Additionally AGPAT4 links with proteins like AGPAT2 in the context of congenital generalized lipodystrophy where defective lipid storage results in severe metabolic complications.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860536873129,"sku":"ab135909","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab135909","provider":"Iright","version":"1.0","type":"link"}