{"product_id":"abcam-ab137083","title":"Abcam, ab137083, Anti-Somatostatin Receptor 1\/SSTR1 antibody [UMB7]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Somatostatin Receptor 1\/SSTR1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 18 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:UMB7,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% EDTA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSomatostatin Receptor 1 (SSTR1) is a G-protein coupled receptor that plays an important role in mediating the effects of the neuropeptide somatostatin. This receptor is often referred to simply as SSTR1 and has a molecular mass of approximately 42 kDa. SSTR1 gets expressed in numerous tissues including the brain kidney and lung. It is known to couple with inhibitory G-proteins leading to reduced adenylate cyclase activity and decreased levels of cyclic AMP which impacts cell signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSSTR1 is important in the regulation of endocrine and neuronal signaling. It does not engage in complex formation but interacts through its pathways to inhibit hormone secretion. In neurons SSTR1 modulates neurotransmitter release impacting processes such as pain perception and neuronal growth. This function extends to controlling cell proliferation influencing cancer cells where it can suppress tumor growth by altering cell-cycle dynamics and inducing apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nSSTR1 plays its role in the somatostatin signaling pathway and the cAMP signaling pathway. Within these pathways it works along with proteins such as adenylate cyclase which it inhibits to relay somatostatin's signals effectively. SSTR1's ability to reduce cAMP levels makes it an important player in signal transduction pathways that govern cell function and communication.\u003cbr\u003e\nSSTR1 has relevance in conditions like acromegaly and neuroendocrine tumors. In acromegaly the receptor's ability to reduce growth hormone secretion is important for symptom management. SSTR1 also relates to neuroendocrine tumors through its interaction with somatostatin which can inhibit tumor growth and progression. In these contexts SSTR1's function intertwines with other somatostatin receptors like SSTR2 to modulate growth hormone release and cell proliferation in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844139864233,"sku":"ab137083","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab137083","provider":"Iright","version":"1.0","type":"link"}