{"product_id":"abcam-ab137492","title":"Abcam, ab137492, Anti-B19 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal B19 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human HUNK aa 650 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human HUNK aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P57058\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHuman parvovirus B19 also known simply as B19 is a small DNA virus with a linear genome and a non-enveloped capsid. The virus itself is approximately 5.6 kilodaltons in mass. B19 targets and infects erythroid progenitor cells in the bone marrow which are critical for red blood cell development. Its expression occurs primarily in tissues with rapid cell turnover such as the bone marrow and B19 is also detectable in fetal liver tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHuman parvovirus B19 acts by binding to the P antigen on susceptible cells particularly erythroid precursors. This interaction facilitates the virus's entry into the cell where it replicates and inhibits cellular DNA synthesis potentially causing cell apoptosis. The virus does not typically form part of a protein complex within the host cell but manipulates host cellular machinery to replicate its own DNA effectively. This mechanism highlights B19's influence in the development of certain anemic conditions such as transient aplastic crisis in patients with hemolytic disorders.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe infection mechanism of human parvovirus B19 involves several cellular pathways including those associated with cell cycle regulation and apoptosis. Notably B19 impacts the retinoblastoma protein (pRb) related pathways which are important in controlling cell cycle progression. Furthermore the virus interferes with tumor suppressor protein p53 disrupting pathways related to DNA damage response. These interactions emphasize the virus's adeptness at manipulating host cell controls to ensure successful replication.\u003cbr\u003e\nInfection with human parvovirus B19 has associations with erythema infectiosum and hydrops fetalis. In individuals with compromised immune systems or those with existing hemolytic anemia B19 infection can aggravate these conditions as the virus exacerbates the reduction of erythroid progenitor cells. The virus shares a relationship with the TNF-alpha protein particularly in inflammatory and autoimmune responses seen in parvovirus-associated arthralgia. This connection underlines the potential for B19 to contribute to a range of pathological conditions through direct and indirect interactions within the host.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854155501737,"sku":"ab137492","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab137492","provider":"Iright","version":"1.0","type":"link"}