{"product_id":"abcam-ab138911","title":"Abcam, ab138911, ATP-gamma-S, Kinase substrate","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nATP-gamma-S (tetralithium salt) (ab138911) is a purinergic (P2Y) receptor agonist. MW: 547.1, Purity \u0026gt; 80%. - Cited in over 30 publications - Acts as kinase substrate and inhibitor of ATP-dependent enzyme systems - Available in different sizes to fit your experimental needs\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:93839-89-5,\u003cbr\u003e\nPurity:\u0026gt;80%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:547.1 Da,\u003cbr\u003e\nMolecular formula:C10H12Li4N5O12P3S,\u003cbr\u003e\nPubChem:5311341,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 10 mM,\u003cbr\u003e\nBiochemical name:Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt,\u003cbr\u003e\nBiological description:Substrate and inhibitor of ATP-dependent enzyme systems. Hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. P2 purinergic receptor agonist.,\u003cbr\u003e\nCanonical smiles:[Li+].[Li+].[Li+].[Li+].C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N,\u003cbr\u003e\nIsomeric smiles:[Li+].[Li+].[Li+].[Li+].C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N,\u003cbr\u003e\nInChi:InChI=1S\/C10H16N5O12P3S.4Li\/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;\/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;\/q;4*+1\/p-4\/t4-,6-,7-,10-;;;;\/m1....\/s1,\u003cbr\u003e\nInChiKey:DWQFDOIBOYDYKH-KWIZKVQNSA-J,\u003cbr\u003e\nIUPAC Name:tetralithium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nKinase reaction reagent to be used with\u003cbr\u003e\nab92570\u003cbr\u003e\nrabbit monoclonal to thiophosphate ester for the identification of direct kinase substrates as mentioned in Allen JJ\u003cbr\u003e\net al.\u003cbr\u003e\nNat Methods 4:511-6 (2007).\u003cbr\u003e\nAfter the kinase of interest has accepted ATP-γ-S,\u003cbr\u003e\n-Nitrobenzyl mesylate (\u003cbr\u003e\nab138910\u003cbr\u003e\n) can be used to alkylate the thiophospholyation site on the substrates. A thiophosphate ester rabbit monoclonal antibody (\u003cbr\u003e\nab92570\u003cbr\u003e\n) is introduced to identify the tagged substrates.\u003cbr\u003e\nFor western blot analysis, we used ATPγS or A*TPγS analogs at a concentration of 1 mM. For kinetic measurements, ATPγS or A*TPγS analog concentration varied from 0.1 μM to 250 μM. See Allen JJ\u003cbr\u003e\net al.\u003cbr\u003e\nNat Methods 4:511-6 (2007); Supp. Material.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions|The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847394807977,"sku":"ab138911","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab138911","provider":"Iright","version":"1.0","type":"link"}