{"product_id":"abcam-ab13896","title":"Abcam, ab13896, Anti-5HT1B Receptor antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal 5HT1B Receptor antibody. Suitable for WB and reacts with Human samples. Cited in 23 publications. Immunogen corresponding to Synthetic Peptide within Rat Htr1b.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Rat Htr1b. The exact immunogen used to generate this antibody is proprietary information.P28564\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-This antibody is affinity purified., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe 5-HT1B receptor also known as the serotonin 1B receptor or HTR1B is a G protein-coupled receptor with a molecular mass of approximately 41 kDa. It binds serotonin an important neurotransmitter in the central nervous system. The 5-HT1B receptor is expressed in various brain regions including the striatum basal ganglia and frontal cortex. This receptor modulates neurotransmission by inhibiting the release of serotonin and other neurotransmitters like dopamine. Interruptions in its function can significantly affect synaptic plasticity and neuronal activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe 5-HT1B receptor plays a role in regulating aggressive behavior mood and appetite. It is part of a larger serotonin receptor family and works in conjunction with other receptor subtypes to maintain effective serotonergic signaling. By influencing dopamine and GABAergic systems the 5-HT1B receptor contributes to neural inhibition and the modulation of reward pathways. Alterations in its activity could influence emotional regulation and various behavioral responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe 5-HT1B receptor participates significantly in the serotonin signaling pathway and MAPK signaling pathway. Interacting with proteins such as G protein-coupled receptor kinases and beta-arrestins it influences downstream effects that include modulation of cAMP levels and changes in phosphatidylinositol turnover. Disturbances in these pathways can affect mood and behavior implicating the 5-HT1B receptor in various neurological pathways.\u003cbr\u003e\nIrregular function of the 5-HT1B receptor links to conditions such as depression and migraine. This receptor through its role in mood regulation implicates it in mood disorders if dysregulated. It also connects to genetic factors influencing migraine possibly through interactions with proteins like calcitonin gene-related peptide (CGRP). Despite the complexity of these conditions the 5-HT1B receptor is a potential target for therapeutic interventions suggesting its importance in disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850161737897,"sku":"ab13896","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab13896","provider":"Iright","version":"1.0","type":"link"}