{"product_id":"abcam-ab139626","title":"Abcam, ab139626, Recombinant Human PYCRL protein","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRecombinant Human PYCRL protein is a Human Full Length protein, in the 1 to 274 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q53H96,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPYCRL also known as Pyrroline-5-carboxylate reductase 3 is an enzyme involved in proline biosynthesis. It catalyzes the conversion of pyrroline-5-carboxylate to proline. This protein has a molecular mass of approximately 29 kDa. It is widely expressed in various tissues including the liver kidney and placenta. Its activity plays an important role in maintaining proline homeostasis within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPYCRL contributes to the cellular process of amino acid metabolism. It participates in a network of enzymatic reactions that balance the levels of proline an amino acid important for protein synthesis and cellular response to osmotic stress. PYCRL forms part of a proline metabolic pathway but does not operate as part of a larger protein complex. By converting pyrroline-5-carboxylate to proline it helps in collagen synthesis and other proline-related functions within the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nPYCRL functionally integrates into the proline biosynthesis pathway. This pathway is essential for amino acid metabolism and stress response. PYCRL works alongside proteins such as ALDH18A1 which synthesizes pyrroline-5-carboxylate from glutamate. The proline pathway not only supports protein production but also impacts cellular stress responses by maintaining proline as an osmoprotectant.\u003cbr\u003e\nProline metabolism dysregulation involving PYCRL has links to certain health conditions. Alterations in this pathway can contribute to hyperprolinemia a metabolic disorder characterized by elevated proline levels. Hyperprolinemia is related to symptoms affecting neurological development. Variations in PYCRL activity might also impact connective tissue disorders due to its role in collagen production. The enzyme is potentially connected with ALDH18A1 through their shared involvement in proline metabolism influencing disease expression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843803238569,"sku":"ab139626","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab139626","provider":"Iright","version":"1.0","type":"link"}