{"product_id":"abcam-ab141011","title":"Abcam, ab141011, Apelin 17, Endogenous apelin receptor (APJ) agonist","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 2138.6 Da, Purity \u0026gt;95%. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:217082-57-0,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:2138.6 Da,\u003cbr\u003e\nMolecular formula:C96H156N34O20S,\u003cbr\u003e\nPubChem:16130452,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 10 mg\/ml,\u003cbr\u003e\nBiochemical name:Apelin precursor (61-77) (human, bovine, mouse, rat) trifluoroacetate,\u003cbr\u003e\nCanonical smiles:CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C5CCCN5C(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC6=CC=CC=C6)NC(=O,\u003cbr\u003e\nIsomeric smiles:CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC6=CC=CC=C6)NC(=O)[C@H](CCCCN)N,\u003cbr\u003e\nInChi:InChI=1S\/C96H156N34O20S\/c1-55(2)47-67(83(140)127-71(53-131)86(143)125-69(50-58-51-109-54-115-58)85(142)116-60(26-11-13-38-98)78(135)114-52-76(133)128-43-18-31-72(128)87(144)122-66(36-46-151-3)91(148)130-45-20-33-74(130)89(146)126-70(92(149)150)49-57-23-8-5-9-24-57)124-81(138)63(29-16-41-112-95(105)106)120-88(145)73-32-19-44-129(73)90(147)65(30-17-42-113-96(107)108)121-82(139)64(34-35-75(100)132)119-80(137)61(27-14-39-110-93(101)102)117-79(136)62(28-15-40-111-94(103)104)118-84(141)68(48-56-21-6-4-7-22-56)123-77(134)59(99)25-10-12-37-97\/h4-9,21-24,51,54-55,59-74,131H,10-20,25-50,52-53,97-99H2,1-3H3,(H2,100,132)(H,109,115)(H,114,135)(H,116,142)(H,117,136)(H,118,141)(H,119,137)(H,120,145)(H,121,139)(H,122,144)(H,123,134)(H,124,138)(H,125,143)(H,126,146)(H,127,140)(H,149,150)(H4,101,102,110)(H4,103,104,111)(H4,105,106,112)(H4,107,108,113)\/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-\/m0\/s1,\u003cbr\u003e\nInChiKey:SVWSKJCJNAIKNH-MJZUAXFLSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]pentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAPJ Receptor also known as the Apelin Receptor or AGTRL1 is part of the G protein-coupled receptor family. The receptor has an approximate mass of 42 kDa and plays a critical role in various physiological processes. APJ is widely expressed in numerous tissues with high concentrations in the brain heart spleen and lungs. The receptor interacts with the peptide ligand apelin acting as an apelin receptor agonist modulating diverse cellular responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAPJ participates in cardiovascular function fluid homeostasis and energy metabolism. The receptor does not form traditional large complexes but works closely with its ligand apelin to exert its effects. APJ influences heart contractility blood vessel formation and blood pressure regulation. In the nervous system it contributes to neuroprotection and fluid balance. This receptor's ability to mediate significant physiological processes makes it an important player in maintaining homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nAPJ receptor engages in both the ACE2-Angiotensin-(1-7)-Mas receptor axis and the PI3K\/AKT signaling pathway. Through these pathways APJ is closely related to other proteins like Mas receptor (MasR) and Angiotensin II. It modulates vasodilation anti-inflammatory responses and apoptosis prevention. By participating in these pathways the APJ receptor helps regulate blood pressure and cardiovascular health.\u003cbr\u003e\nAPJ receptor has a significant impact on cardiovascular diseases and metabolic disorders such as hypertension and diabetes. It relates to other proteins like the renin-angiotensin system (RAS) components contributing to blood vessel constriction and fluid balance disruptions. Targeting the APJ receptor with apelin agonists or antagonists provides potential therapeutic avenues for managing cardiovascular issues and addressing metabolic dysregulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847432818857,"sku":"ab141011","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab141011","provider":"Iright","version":"1.0","type":"link"}