{"product_id":"abcam-ab141183","title":"Abcam, ab141183, Clomiphene citrate, Estrogen receptor modulator (SERM)","description":"\u003cp\u003eSize: 1g\u003cbr\u003e\nMW 598.1 Da, Purity \u0026gt;98%. Selective estrogen receptor modulator (SERM) (IC 50  = 16 μM). Able to regulate apoptosis in tissue and cellular targets of estrogen signaling. Displays antiproliferative effects  in vitro . Active  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:50-41-9,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:598.1 Da,\u003cbr\u003e\nMolecular formula:C32H36ClNO8,\u003cbr\u003e\nPubChem:60974,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 10 mM,\u003cbr\u003e\nBiochemical name:Clomiphene citrate,\u003cbr\u003e\nBiological description:Selective estrogen receptor modulator (SERM) (IC50 = 16 μM). Able to regulate apoptosis in tissue and cellular targets of estrogen signaling. Displays antiproliferative effects in vitro. Active in vivo.,\u003cbr\u003e\nCanonical smiles:CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O,\u003cbr\u003e\nInChi:InChI=1S\/C26H28ClNO.C6H8O7\/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10\/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12),\u003cbr\u003e\nInChiKey:PYTMYKVIJXPNBD-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe targets listed such as Progesterone Receptor and Vitamin D Receptor are important proteins with distinct mechanical actions. Progesterone Receptor (PR) and Androgen Receptor (AR) are nuclear hormone receptors that bind to their respective ligands to modulate gene expression. PR is approximately 99 kDa in mass and is widely expressed in reproductive tissues. Gli3 functions as a transcription factor playing a part in the Hedgehog signaling pathway. Maxi Potassium channels consist of alpha subunits (SLO) and beta subunits (KCNMB1 KCNMB2 KCNMB4 LRRC26) with the alpha subunit primarily responsible for the channel's pore-forming activities. Retinoic Acid Receptor alpha (RARα) interacts with retinoids to regulate gene transcription. Aromatase is an enzyme that converts androgens to estrogens important in steroid metabolism. Proteins like Estrogen Related Receptor alpha (ERRα) and ROR gamma act as nuclear receptors modulating transcriptional activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins are involved in various regulatory mechanisms within cells. Progesterone Receptor and Androgen Receptor are critical in regulating reproductive and sexual development. The Vitamin D Receptor (VDR) binds to Vitamin D to regulate calcium homeostasis and bone health. The Maxi Potassium channels regulate neuronal excitability and muscle contraction through ion transport. The Aromatase enzyme plays a significant role in estrogen biosynthesis linking hormone synthesis with metabolic processes. Progesterone estrogen androgens and vitamin D receptors often form complexes with co-activators or co-repressors influencing numerous gene expression programs.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese targets integrate into many critical signal transduction pathways. Progesterone and Androgen Receptors are embedded within the steroid hormone pathway influencing other proteins like SRC1 and TIF2 which are co-activators. Vitamin D Receptor functions in the calcium signaling pathway important for bone mineralization aligning with transcriptional regulators such as RXR. ROR gamma and ERRα participate in both metabolism-related pathways and immune regulation pathways. These proteins interact with various signaling molecules to modulate cellular responses and ensure proper physiological balance.\u003cbr\u003e\nThese targets associate with several conditions. Anomalies in Androgen Receptor expression can lead to androgen insensitivity syndrome while malfunction of the Progesterone Receptor can contribute to breast cancer. Aberrant function of the Aromatase enzyme is often linked with estrogen-dependent tumors such as those in breast cancer. Mutations in Vitamin D Receptor may result in rickets a bone disorder due to impaired calcium absorption. These targets are connected to numerous other proteins like estrogen receptor in breast cancer impacting their pathways and roles in disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847449170089,"sku":"ab141183","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab141183","provider":"Iright","version":"1.0","type":"link"}