{"product_id":"abcam-ab141405","title":"Abcam, ab141405, PP242, mTOR inhibitor","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 308.34 Da, Purity \u0026gt;98%. Potent, selective and ATP-competitive mTOR inhibitor (IC 50  = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1\/eIF-4E\/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC 50  values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active  in vivo  and  in vitro .\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nMolecular weight:308.34 Da,\u003cbr\u003e\nMolecular formula:C16H16N6O,\u003cbr\u003e\nPubChem:25243800,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:CID 25243800,\u003cbr\u003e\nBiological description:Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 8 nM). Inhibits both mTORC1 and mTORC2. Activates ERK via TORC1\/eIF-4E\/RAF pathway in cancer cells. Selective for mTOR over PI3K family kinases (IC50 values are 0.1 (p110γ), 0.41 (DNA-PK), 1.27 (p110δ), 1.96 (p110α) and 2.2 (p110β) μM). Anticancer agent. Active in vivo and in vitro.,\u003cbr\u003e\nCanonical smiles:CC(C)N1C2=NC=NC(=C2C(=C3C=C4C=C(C=CC4=N3)O)N1)N,\u003cbr\u003e\nIsomeric smiles:CC(C)N1C2=NC=NC(=C2\/C(=C\\3\/C=C4C=C(C=CC4=N3)O)\/N1)N,\u003cbr\u003e\nInChi:InChI=1S\/C16H16N6O\/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12\/h3-8,21,23H,1-2H3,(H2,17,18,19)\/b14-12+,\u003cbr\u003e\nInChiKey:MTICIDWIKCANDD-WYMLVPIESA-N,\u003cbr\u003e\nIUPAC Name:(2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1658 PP242. 1658-1 is the same size as the 1 mg size of ab141405.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847474958505,"sku":"ab141405","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab141405","provider":"Iright","version":"1.0","type":"link"}