{"product_id":"abcam-ab141475","title":"Abcam, ab141475, Vinblastine sulfate, Microtubule dynamics inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 909.1 Da, Purity \u0026gt;95%. Potent microtubule dynamics inhibitor. Inhibits tubulin addition (K i  = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC 50  = 1 nM). Antitumor effects  in vivo.  .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:143-67-9,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:909.1 Da,\u003cbr\u003e\nMolecular formula:C46H58N4O9.H2O4S,\u003cbr\u003e\nPubChem:241902,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Vincaleukoblastine sulfate,\u003cbr\u003e\nBiological description:Potent microtubule dynamics inhibitor. Inhibits tubulin addition (Ki = 0.18 μM). Suppresses mitotic spindle formation. Induces apoptosis. Vincristine (ab120226) analog. Potent antiproliferative effects (IC50 = 1 nM). Antitumor effects in vivo.,\u003cbr\u003e\nCanonical smiles:CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,\u003cbr\u003e\nIsomeric smiles:CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C46H58N4O9.H2O4S\/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4\/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)\/t28-,37+,38-,39-,42+,43-,44-,45+,46+;\/m1.\/s1,\u003cbr\u003e\nInChiKey:KDQAABAKXDWYSZ-JKDPCDLQSA-N,\u003cbr\u003e\nIUPAC Name:methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1959 Vinblastine Sulfate. 1959-25 is the same size as the 25 mg size of ab141475.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTubulin is a family of globular proteins and essential components of microtubules which play an important role in maintaining cellular structure and facilitating intracellular transport. The beta-tubulins including beta III beta I beta IV beta II and alpha tubulin have molecular masses ranging around 50 kDa. Tubulin proteins are expressed in various tissues with beta-tubulin III expressing highly in neurons. Alternate names for tubulin include TUBA1C TUBA1A TUBB2A TUBB8 TUBB2B TUBB6 and TUBA3E. These proteins contribute to the assembly of microtubules influencing their dynamics and stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTubulin proteins form part of the microtubule complex which is fundamental to cellular processes such as mitosis and intracellular transport. These proteins influence microtubule dynamics important in chromosome segregation and signaling pathways involving cell movement and division. Tubulin interacts with various chemical structures such as vinblastine which affects microtubule polymerization. The dynamic instability of microtubules is important for their role in cell cycle progression and neuronal development.\u003cbr\u003e\nPathways\u003cbr\u003e\nTubulin family proteins participate in significant pathways like the mitotic spindle assembly and axonal transport. These pathways have implications in the regulation of cell cycle and neuronal functioning. Related proteins within these pathways include kinesins and dyneins which are motor proteins that transport cellular cargo along microtubules. The regulation of these pathways ensures proper cell division and neuronal signaling which are essential for organismal development and homeostasis.\u003cbr\u003e\nTubulin is linked with neurodegenerative diseases such as Alzheimer's disease and cancer. Tubulin dysfunction can impact microtubule assembly leading to errors in chromosome segregation and neuronal damage. Proteins connected to tubulin dysfunction include tau protein in Alzheimer's disease which aggregates and disturbs microtubule stability. In cancer aberrant tubulin activity may influence the effectiveness of chemotherapeutic agents targeting microtubule dynamics potentially impacting treatment outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847479546025,"sku":"ab141475","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab141475","provider":"Iright","version":"1.0","type":"link"}