{"product_id":"abcam-ab141842","title":"Abcam, ab141842, Penitrem A, blocker of KCa1.1","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 634.2 Da, Purity \u0026gt;98%. Potent, selective BK Ca  blocker (IC 50  values are 6 and 60 nM for α-subunit and mixed α- and β 1 -subunit containing channels respectively). No effect on native delayed rectifier K +  currents, cloned voltage-dependent K v1.5  channels, or K ATP  currents. Inhibits BK channels in inside-out and cell-attached patches. Tremorgenic effects and increases total peripheral resistance  in vivo . Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:12627-35-9,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nSource:Penicillium palitans,\u003cbr\u003e\nMolecular weight:634.2 Da,\u003cbr\u003e\nMolecular formula:C37H44ClNO6,\u003cbr\u003e\nPubChem:44450809,\u003cbr\u003e\nNature:Native,\u003cbr\u003e\nSolubility:Soluble in DMSO to 10 mM,\u003cbr\u003e\nBiochemical name:(1S,2R,5S,6R,8S,9S,10R,12S,15R,16S,25R,27S,28R)-21-chloro-15,16,33,33-tetramethyl-24-methylidene-10-prop-1-en-2-yl-7,11,32-trioxa-18-azadecacyclo[25.4.2.02,16.05,15.06,8.06,12.017,31.019,30.022,29.025,28]tritriaconta-17(31),19,21,29-tetraene-5,9,28-triol,\u003cbr\u003e\nBiological description:Potent, selective BKCa blocker (IC50 values are 6 and 60 nM for α-subunit and mixed α- and β1-subunit containing channels respectively). No effect on native delayed rectifier K+ currents, cloned voltage-dependent Kv1.5 channels, or KATP currents. Inhibits BK channels in inside-out and cell-attached patches. Tremorgenic effects and increases total peripheral resistance in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8CC9C8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O,\u003cbr\u003e\nIsomeric smiles:CC(=C)[C@@H]1[C@@H]([C@H]2[C@]3(O2)[C@@H](O1)CC[C@]4([C@]3(CC[C@@H]5[C@@]4(C6=C7[C@H]5OC([C@H]8C[C@H]9[C@@]8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O,\u003cbr\u003e\nInChi:InChI=1S\/C37H44ClNO6\/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24\/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3\/t18-,19+,22+,23-,27-,28+,29-,31-,33+,34+,35-,36+,37+\/m0\/s1,\u003cbr\u003e\nInChiKey:JDUWHZOLEDOQSR-OBPHCMCKSA-N,\u003cbr\u003e\nIUPAC Name:(1S,2R,5S,6R,8S,9S,10R,12S,15R,16S,25R,27S,28R)-21-chloro-15,16,33,33-tetramethyl-24-methylidene-10-prop-1-en-2-yl-7,11,32-trioxa-18-azadecacyclo[25.4.2.02,16.05,15.06,8.06,12.017,31.019,30.022,29.025,28]tritriaconta-17(31),19,21,29-tetraene-5,9,28-triol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847473549481,"sku":"ab141842","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab141842","provider":"Iright","version":"1.0","type":"link"}