{"product_id":"abcam-ab143002","title":"Abcam, ab143002, Tianeptine sodium, 5-HT uptake facilitator","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 458.9 Da, Purity \u0026gt;99%. Selective 5-HT uptake facilitator. Shows antidepressant, analgesic, neuroprotective and cognitive enhancing effects  in vivo.  Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:30123-17-2,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:458.9 Da,\u003cbr\u003e\nMolecular formula:C21H24ClN2NaO4S,\u003cbr\u003e\nPubChem:23663953,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Tianeptine sodium,\u003cbr\u003e\nBiological description:Selective 5-HT uptake facilitator. Shows antidepressant, analgesic, neuroprotective and cognitive enhancing effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CN1C2=CC=CC=C2C(C3=C(S1(=O)=O)C=C(C=C3)Cl)NCCCCCCC(=O)[O-].[Na+],\u003cbr\u003e\nInChi:InChI=1S\/C21H25ClN2O4S.Na\/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;\/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);\/q;+1\/p-1,\u003cbr\u003e\nInChiKey:ZLBSUOGMZDXYKE-UHFFFAOYSA-M,\u003cbr\u003e\nIUPAC Name:sodium;7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions|The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPXR also known as the pregnane X receptor or NR1I2 is a nuclear receptor involved in the regulation of gene expression. It plays a significant role in detoxification processes. PXR has a molecular mass of approximately 49 kDa. This receptor is primarily expressed in the liver and intestine where it mediates the induction of enzymes important in metabolizing xenobiotics and endobiotics. Notably PXR activation leads to the expression of cytochrome P450 enzymes including CYP3A4 which are essential in drug metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe pregnane X receptor is an important sensor in the body's defense system against potentially harmful compounds. PXR forms a heterodimer complex with the retinoid X receptor (RXR) to exert its function. It binds to response elements in the promoter regions of target genes to regulate their transcription. This receptor is highly responsive to a variety of ligands including medications like buy tiagabine and endogenous steroids such as the pregnanolone chemical structure. Ligands binding to PXR result in the transcriptional upregulation of genes involved in several metabolic pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe pregnane X receptor has significant roles in the regulation of drug metabolism and disposition pathways. PXR activation leads to the induction of detoxifying enzymes and transporters prominently within the xenobiotic metabolism pathway. It is closely linked with CYP450 enzymes particularly CYP3A4 and the transport protein MDR1. These proteins work together to increase the metabolism and clearance of a variety of drugs and toxins thereby protecting the organism from potential harm.\u003cbr\u003e\nPXR is associated with conditions involving drug-induced liver injury and inflammatory bowel disease. Its regulation of CYP3A4 impacts the metabolism of various drugs which can lead to altered efficacy or toxicity as seen in these conditions. Additionally PXR dysregulation has implications in liver diseases where nuclear receptors are critical for maintaining metabolic homeostasis. Interactions between PXR and other nuclear receptors like the constitutive androstane receptor (CAR) further demonstrate its involvement in hepatic health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847472959657,"sku":"ab143002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab143002","provider":"Iright","version":"1.0","type":"link"}