{"product_id":"abcam-ab144402","title":"Abcam, ab144402, SB 505124, ALK5 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 335.4 Da, Purity \u0026gt;98%. Potent, reversible, competitive ALK5 inhibitor (IC 50  values are 47 and 129 nM for ALK5 and ALK4 respectively). Inhibits ALK7 but not ALK1, 2, 3, or 6. Shows antifibrotic effects  in vivo.  .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:356559-13-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:335.4 Da,\u003cbr\u003e\nMolecular formula:C20H21N3O2,\u003cbr\u003e\nPubChem:9858940,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine,\u003cbr\u003e\nBiological description:Potent, reversible, competitive ALK5 inhibitor (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Inhibits ALK7 but not ALK1, 2, 3, or 6. Shows antifibrotic effects in vivo.,\u003cbr\u003e\nCanonical smiles:CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4,\u003cbr\u003e\nInChi:InChI=1S\/C20H21N3O2\/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15\/h5-10H,11H2,1-4H3,(H,22,23),\u003cbr\u003e\nInChiKey:WGZOTBUYUFBEPZ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe p38 kinase also known as MAPK14 weighs about 41 kDa. It is expressed in many tissues such as the heart brain skeletal muscle and liver. Mechanically it acts as a serine\/threonine kinase part of the mitogen-activated protein kinase (MAPK) family. RIP2 or receptor-interacting serine\/threonine-protein kinase 2 is associated with receptor complexes in immune responses. TGF beta Receptor I also known as ALK-5 is a part of the TGF-beta receptor complex and is widely expressed in various tissues. Activin A Receptor Type IB or ALK-4 has a mass of 56 kDa and shows expression in the ovary muscle and brain. ROR gamma or retinoic acid receptor-related orphan receptor gamma is expressed largely in lymphoid tissues especially in the thymus.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nP38 kinase functions include the transmission of signals for inflammation cell differentiation and apoptosis. It often functions as part of larger pathways like the MAPK cascade. RIP2 participates in innate immune responses functioning within the NOD1\/2 signaling complex. TGF beta Receptor I mediates the TGF-beta signaling pathways that regulate cell growth and differentiation often associating with type II receptors to form heterodimers. Activin A Receptor Type IB can form a complex with type II receptors to modulate reproductive and developmental processes. ROR gamma plays an important role in the development of immune cell lineages and circadian rhythm regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nP38 kinase plays a significant role in the MAPK signaling pathway and is linked with proteins like JNK and ERK which are also part of MAPK family. RIP2 is pivotal in the NOD-like receptor signaling pathway engaging proteins like CARD9 for facilitating immune responses. TGF beta Receptor I being integral to the TGF-beta signaling pathway interacts heavily with SMAD proteins. Activin A Receptor Type IB fits into the Activin signaling pathway which involves different SMAD proteins. ROR gamma is involved in the nuclear receptor signaling pathway interacting with proteins such as ROR alpha and dermokine for metabolic and developmental regulation.\u003cbr\u003e\nThe p38 kinase association includes inflammatory diseases and cancer engaging with proteins like NF-kB that mediate inflammation. Alterations in RIP2 can lead to inflammatory disorders such as Crohn's disease with connections to inflammatory cytokines. TGF beta Receptor I frequently links to fibrosis and cancer as it engages pathways involving SMAD3. Mutations or dysregulation of Activin A Receptor Type IB often relate to reproductive disorders and cancers interacting with proteins such as Follistatin. ROR gamma is involved in autoimmune diseases such as psoriasis affecting the function of IL-17-producing immune cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847443206313,"sku":"ab144402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab144402","provider":"Iright","version":"1.0","type":"link"}