{"product_id":"abcam-ab144421","title":"Abcam, ab144421, CAY 10566, SCD1 inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 25mg\u003cbr\u003e\nMW 389.8 Da, Purity \u0026gt;99%. Potent, selective SCD1 inhibitor (IC 50  values are 4.5 and 26 nM in mouse and human SCD1, respectively). Inhibits saturated, long-chain fatty acyl-CoAs conversion to monounsaturated, long-chain fatty acyl-CoAs (IC 50  values are 7.9 and 6.8 nM for heptadecanoic acid and palmitic acid, respectively).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:944808-88-2,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:389.8 Da,\u003cbr\u003e\nMolecular formula:C18H17ClFN5O2,\u003cbr\u003e\nPubChem:16732433,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole,\u003cbr\u003e\nBiological description:Potent, selective SCD1 inhibitor (IC50 values are 4.5 and 26 nM in mouse and human SCD1, respectively). Inhibits saturated, long-chain fatty acyl-CoAs conversion to monounsaturated, long-chain fatty acyl-CoAs (IC50 values are 7.9 and 6.8 nM for heptadecanoic acid and palmitic acid, respectively).,\u003cbr\u003e\nCanonical smiles:CC1=NN=C(O1)C2=NN=C(C=C2)N3CCC(CC3)OC4=C(C=CC(=C4)F)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C18H17ClFN5O2\/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19\/h2-5,10,13H,6-9H2,1H3,\u003cbr\u003e\nInChiKey:WFOFPVXMPTVOTJ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]-5-methyl-1,3,4-oxadiazole\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nStearoyl-CoA desaturase-1 (SCD1) also known as delta-9-desaturase is an enzyme integral to the synthesis of monounsaturated fats. This enzyme converts saturated fatty acyl-CoAs to monounsaturated fatty acyl-CoAs by introducing a double bond between the ninth and tenth carbon atoms a process called desaturation. SCD1 has a molecular weight of approximately 45 kDa and expresses in a variety of tissues including the liver adipose tissue and heart.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSCD1 plays a significant role in fatty acid metabolism by regulating the balance of saturated and unsaturated fatty acids which impacts membrane fluidity and cellular signaling. SCD1 does not function as part of a multi-protein complex acting independently in the endoplasmic reticulum. Its expression and activity influence lipid biosynthesis and storage affecting energy homeostasis and lipid composition in cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nFatty acid synthesis and oxidation pathways extensively involve SCD1. It participates mainly in the lipogenesis pathway interacting with proteins like acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). SCD1 contributes to maintaining the ratio of oleate and palmitoleate key monounsaturated fatty acids important for cellular functions by integrating into the lipid metabolism network.\u003cbr\u003e\nSCD1 is implicated in conditions like obesity and metabolic syndrome. Altered SCD1 activity links to insulin resistance as seen in obesity by modulating lipid profiles that influence insulin sensitivity. SCD1 associates with proteins like peroxisome proliferator-activated receptor gamma (PPARγ) which regulates adipogenesis emphasizing its role in metabolic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847396741289,"sku":"ab144421","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab144421","provider":"Iright","version":"1.0","type":"link"}