{"product_id":"abcam-ab145064","title":"Abcam, ab145064, 1-Naphthyl PP1, PKD inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 317.4 Da, Purity \u0026gt;99%. ATP-competitive PKD inhibitor. Antiproliferative agent. Inhibits tumor cell invasion and induces G 2 \/M arrest. ATP and PP1 analog.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:221243-82-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:317.4 Da,\u003cbr\u003e\nMolecular formula:C19H19N5,\u003cbr\u003e\nPubChem:4877,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine,\u003cbr\u003e\nBiological description:ATP-competitive PKD inhibitor. Antiproliferative agent. Inhibits tumor cell invasion and induces G2\/M arrest. ATP and PP1 analog.,\u003cbr\u003e\nCanonical smiles:CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N,\u003cbr\u003e\nInChi:InChI=1S\/C19H19N5\/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14\/h4-11H,1-3H3,(H2,20,21,22),\u003cbr\u003e\nInChiKey:XSHQBIXMLULFEV-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-tert-butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target list comprises several kinases and regulatory proteins including PKC (Protein Kinase C) Cdks (Cyclin-dependent kinases) JNK1 (c-Jun N-terminal kinase 1) RIP2 (Receptor-interacting protein 2) CSK (C-terminal Src kinase) PKC mu\/PKD (Protein kinase D) Fyn Lck (Lymphocyte-specific protein tyrosine kinase) CaMKII alpha (Calcium\/calmodulin-dependent protein kinase II alpha) ABL1 and Casein Kinase 1 delta\/CSNK1D. These proteins perform a variety of functions inside cells. For example PKC with a mass varying between 77 to 99 kDa depending on the isoform is expressed in various tissues and plays roles in signal transduction. Cdks act mostly in regulating the cell cycle. The proteins are located ubiquitously in cellular membranes cytosol and the nucleus depending on their roles and activation states.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe proteins listed above participate in essential cellular processes including signal transduction cell cycle control apoptosis and response to stress. For instance PKC is an important player in pathways controlling cellular responses to signals. Cdks bind to regulatory proteins called cyclins to regulate cell cycle transitions. These proteins often exist as parts of larger complexes to exert their functions. Many kinases such as JNK1 and RIP2 modulate immune and inflammatory responses while CSK negatively regulates Src family kinases by phosphorylation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese proteins integrate into various essential biological pathways. PKC and CDKs play pivotal roles in the cell cycle and signaling pathways impacting cell growth and apoptosis. JNK1 is involved in the MAPK (Mitogen-activated protein kinase) pathway interacting with stress-related stimuli. In this network Fyn and Lck are non-receptor tyrosine kinases that participate in T-cell receptor signaling. CaMKII alpha ABL1 and Casein Kinase 1 delta also integrate into pathways related to cellular architecture and neurochemical responses.\u003cbr\u003e\nPKC Cdks and JNK1 are implicated in cancer and neurodegenerative disorders such as Alzheimer's disease. Aberrant PKC expression and Cdks deregulation contribute to tumor development and progression. Similarly ABL1 when activated in BCR-ABL fusion is associated with chronic myeloid leukemia. CSK and Lck dysregulation are involved in autoimmune diseases through their roles in immune signaling pathways underlining their connection in pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847486263465,"sku":"ab145064","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab145064","provider":"Iright","version":"1.0","type":"link"}