{"product_id":"abcam-ab145226","title":"Abcam, ab145226, BML 280, PLD2 inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 429.5 Da, Purity \u0026gt;98%. Potent, selective PLD2 inhibitor (IC 50  values are 90 and 500 nM for HEK293 and human cells respectively).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1158347-73-9,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nMolecular weight:429.5 Da,\u003cbr\u003e\nMolecular formula:C25H27N5O2,\u003cbr\u003e\nPubChem:44138050,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 50 mMSoluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)quinoline-3-carboxamide,\u003cbr\u003e\nBiological description:Potent, selective PLD2 inhibitor (IC50 values are 90 and 500 nM for HEK293 and human cells respectively).,\u003cbr\u003e\nCanonical smiles:C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5N=C4,\u003cbr\u003e\nInChi:InChI=1S\/C25H27N5O2\/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21\/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32),\u003cbr\u003e\nInChiKey:WJOCDBUFEUKYNI-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPhospholipase D1 (PLD1) and Phospholipase D2 (PLD2) are enzymes that hydrolyze phosphatidylcholine to produce phosphatidic acid and choline. PLD1 and PLD2 are isoforms with significant roles in cellular functions. PLD1 has a molecular mass of approximately 120 kDa and is widely expressed in various tissues including the brain liver and heart. Alternate names for PLD1 include PLD1A and hPLD1. PLD2 similar in structure shares overlapping functions with PLD1. Both isoforms are localized in cellular membranes where they perform their enzymatic activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPLD enzymes participate in signal transduction and membrane trafficking. PLD1 and PLD2 play roles in vesicle transport cytoskeletal organization and cellular proliferation. They are not typically part of large multiprotein complexes however they associate with other proteins like protein kinase C and small GTPases during signal transduction. By influencing intracellular pathways PLD1 and PLD2 contribute to diverse physiological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nPLD1 and PLD2 are key players in the phosphatidylinositol signaling system and the mTOR pathway. Within the phosphatidylinositol signaling system PLD1 and PLD2 work with proteins like phosphatidylinositol 3-kinase (PI3K) helping regulate cell survival and growth. In the mTOR pathway which connects nutrient availability to cellular growth these enzymes interact with mTOR complexes affecting protein synthesis and autophagy.\u003cbr\u003e\nPLD1 and PLD2 have implications in cancer and neurological disorders. In cancer upregulation of PLD enzymes associates with tumorigenesis and metastasis potentially through interactions with proteins like Ras and Rho GTPases. In neurological disorders aberrant PLD activity links to Alzheimer's disease where PLD enzymes may interact with amyloid precursor protein influencing amyloid-beta production. Understanding PLD1 and PLD2 functions offers insights into therapeutic strategies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847475024041,"sku":"ab145226","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab145226","provider":"Iright","version":"1.0","type":"link"}