{"product_id":"abcam-ab146170","title":"Abcam, ab146170, FLI-06, Notch signaling inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 438.5 Da. Notch signaling inhibitor (EC 50  of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling  in vivo.  .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:313967-18-9,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:438.5 Da,\u003cbr\u003e\nMolecular formula:C25H30N2O5,\u003cbr\u003e\nPubChem:3103157,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 10 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate,\u003cbr\u003e\nBiological description:Notch signaling inhibitor (EC50 of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling in vivo.,\u003cbr\u003e\nCanonical smiles:CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4,\u003cbr\u003e\nInChi:InChI=1S\/C25H30N2O5\/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28\/h9-12,18,22,26H,4-8,13-14H2,1-3H3,\u003cbr\u003e\nInChiKey:SWWVFYHSSOWZMF-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847449071785,"sku":"ab146170","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab146170","provider":"Iright","version":"1.0","type":"link"}