{"product_id":"abcam-ab146412","title":"Abcam, ab146412, CCT 018159, Hsp90 ATPase inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 352.39 g\/mol, Purity \u0026gt;98%. Selective, cell-permeable Hsp90 ATPase inhibitor (IC 50  values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1\/DT-diaphorase and P-glycoprotein expression.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:171009-07-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:352.39 g\/mol,\u003cbr\u003e\nMolecular formula:C20H20N2O4,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiological description:Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1\/DT-diaphorase and P-glycoprotein expression.,\u003cbr\u003e\nCanonical smiles:CCC1CC(C(CC1O)O)C2C(C([NH]N2)C)C3CCC4C(C3)OCCO4,\u003cbr\u003e\nInChi:InChI=1S\/C20H20N2O4\/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17\/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22),\u003cbr\u003e\nInChiKey:OWPMENVYXDJDOW-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847428198569,"sku":"ab146412","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab146412","provider":"Iright","version":"1.0","type":"link"}