{"product_id":"abcam-ab146582","title":"Abcam, ab146582, CHIR 98014, ATP-competitive GSK3 inhibitor","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 486.3 Da, Purity \u0026gt;98%. Potent, selective ATP-competitive GSK3 inhibitor (IC 50  values are 0.58 and 0.65 nM for GSKα and GSKβ respectively). Potently activates the Wnt\/β-catenin signaling pathway. CHIR 98014 (ab146582) solution.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:252935-94-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:486.3 Da,\u003cbr\u003e\nMolecular formula:C20H17Cl2N9O2,\u003cbr\u003e\nPubChem:53396311,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 5 mM,\u003cbr\u003e\nBiochemical name:6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine,\u003cbr\u003e\nBiological description:Potent, selective ATP-competitive GSK3 inhibitor (IC50 values are 0.58 and 0.65 nM for GSKα and GSKβ respectively). Potently activates the Wnt\/β-catenin signaling pathway. CHIR 98014 (ab146582) solution.,\u003cbr\u003e\nCanonical smiles:C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N,\u003cbr\u003e\nInChi:InChI=1S\/C20H17Cl2N9O2\/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17\/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29),\u003cbr\u003e\nInChiKey:MDZCSIDIPDZWKL-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2595 CHIR-98014. 2595-5 is the same size as the 5 mg size of ab146582.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlycogen synthase kinase 3 beta (GSK3β) and glycogen synthase kinase 3 alpha (GSK3α) are serine\/threonine protein kinases involved in various cellular processes. GSK3β weighs approximately 47 kDa while GSK3α is around 51 kDa. These proteins are expressed in various tissues including brain heart and liver. GSK3 isoforms act as key regulators in signaling pathways by phosphorylating target proteins affecting their function and stability. Alternative names for GSK3 include GSK-3β and GSK-3α respectively.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe kinases play essential roles in cellular functions like glycogen metabolism cell cycle regulation and apoptosis. GSK3 proteins often function as part of larger enzyme complexes influencing cellular responses to external signals. They bind to numerous substrates impacting processes such as glucose homeostasis and neuron function. Dramatic changes in GSK3 activity can disrupt these biological processes highlighting their importance.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese kinases are integral components of the Wnt\/β-catenin and insulin signaling pathways. In the Wnt pathway GSK3 is involved in β-catenin phosphorylation affecting its degradation and transcriptional activity. In the insulin pathway GSK3 influences glycogen synthesis by phosphorylating and regulating glycogen synthase. Both pathways highlight how GSK3 interacts with other proteins such as adenomatous polyposis coli (APC) and axin to coordinate cellular activities.\u003cbr\u003e\nGSK3 has links to conditions like Alzheimer's disease and diabetes mellitus. Dysregulation of GSK3 activity is observed in Alzheimer's disease where abnormal GSK3 signaling contributes to tau hyperphosphorylation and neurofibrillary tangle formation. In diabetes altered GSK3 function affects insulin signaling pathways influencing glucose metabolism. GSK3's involvement in these diseases often connects it to proteins like tau in Alzheimer's and insulin receptor substrate 1 (IRS1) in diabetes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847486165161,"sku":"ab146582","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab146582","provider":"Iright","version":"1.0","type":"link"}