{"product_id":"abcam-ab146970","title":"Abcam, ab146970, T2AA, Proliferating cell nuclear antigen (PCNA) inhibitor","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 511.09 Da, Purity \u0026gt;98%. Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA\/PIP-box peptide interaction (IC 50  = ~1 μM). Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Causes DNA replication stress by stalling DNA replication forks. Suppresses cancer cell growth. T3 derivative that exhibits almost no thyroid hormone activity.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1380782-27-3,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:511.09 Da,\u003cbr\u003e\nMolecular formula:C15H15I2NO3,\u003cbr\u003e\nPubChem:71185540,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:4-{4-[(2s)-2-Amino-3-Hydroxypropyl]-2,6-Diiodophenoxy}phenol,\u003cbr\u003e\nBiological description:Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA\/PIP-box peptide interaction (IC50 = ~1 μM). Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Causes DNA replication stress by stalling DNA replication forks. Suppresses cancer cell growth. T3 derivative that exhibits almost no thyroid hormone activity.,\u003cbr\u003e\nCanonical smiles:C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(CO)N)I,\u003cbr\u003e\nIsomeric smiles:C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)C[C@@H](CO)N)I,\u003cbr\u003e\nInChi:InChI=1S\/C15H15I2NO3\/c16-13-6-9(5-10(18)8-19)7-14(17)15(13)21-12-3-1-11(20)2-4-12\/h1-4,6-7,10,19-20H,5,8,18H2\/t10-\/m0\/s1,\u003cbr\u003e\nInChiKey:NKOSKXJRVWVXRI-JTQLQIEISA-N,\u003cbr\u003e\nIUPAC Name:4-[4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy]phenol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPCNA or Proliferating Cell Nuclear Antigen functions as a sliding clamp for DNA polymerases during DNA replication. This important role enables it to coordinate the orderly duplication of the genome by increasing the processivity of DNA polymerase δ. PCNA weighs approximately 29 kDa and forms a homotrimeric ring structure. It is expressed in the nucleus of cells often found abundantly in proliferating cells. Aside from its main name some people also refer to it as PC10.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein serves a core function in cell cycle regulation and DNA repair. PCNA acts as a scaffold for the assembly of numerous proteins involved in DNA processing forming part of the replication fork complex. It interacts with cyclins and cyclin-dependent kinases (CDKs) linking DNA synthesis to cell cycle progression. Furthermore PCNA partners with proteins involved in DNA mismatch repair base excision repair and nucleotide excision repair.\u003cbr\u003e\nPathways\u003cbr\u003e\nPCNA is integral in the DNA replication and repair pathways. It closely associates with the p21 protein which regulates the cell cycle by inhibiting cyclin-CDK complexes upon DNA damage. PCNA also plays a part in the ubiquitin-proteasome pathway where its modification by ubiquitin impacts how cells respond to DNA damage. This modification recruits specific proteins for DNA repair highlighting its central role in maintaining genomic stability.\u003cbr\u003e\nPCNA is linked to cancer and autoimmune diseases. Its overexpression is common in various cancers reflecting its role in cell proliferation and the cell cycle. PCNA antibodies are sometimes found in the serum of patients with systemic lupus erythematosus (SLE) a connection also related to alterations in the p21 protein pathway. The interaction between PCNA and disease-specific proteins emphasizes its importance in both cell proliferation and immune system disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847442649257,"sku":"ab146970","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab146970","provider":"Iright","version":"1.0","type":"link"}