{"product_id":"abcam-ab150684","title":"Abcam, ab150684, Reticulum Stain Kit (Connective Tissue Stain)","description":"\u003cp\u003eSize: 100Test\u003cbr\u003e\nThe Reticulum Stain Kit (Connective Tissue Stain) is intended for use in histological demonstration of reticular fibers.\u003cbr\u003e\nKey facts\u003cbr\u003e\nSample types:Tissue sections\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe Reticulum Stain Kit (Connective Tissue Stain) is intended for use in histological demonstration of reticular fibers. The main function of reticular fibers is to provide support. They are normally found throughout the body, particularly in liver, lymph node, spleen and kidney. Ammoniacal silver stains are the most commonly used methods for demonstration of reticular fibers.\u003cbr\u003e\nOther products for staining tissue sections\u003cbr\u003e\nFind more kits and reagents in the\u003cbr\u003e\nspecial stains guide\u003cbr\u003e\n, or products for antigen retrieval, blocking, signal amplification, visualization, counterstaining, and mounting in the\u003cbr\u003e\nIHC kits and reagents guide\u003cbr\u003e\nStaining Interpretation\u003cbr\u003e\nReticulum\u003cbr\u003e\nNuclei\u003cbr\u003e\nControl Tissue:\u003cbr\u003e\nLiver, Kidney, Lymph Node, Spleen\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-Multi, Storage information-Please refer to protocols\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nReticular fibers also known as reticulin fibers serve as a supportive scaffolding in connective tissues. They primarily consist of type III collagen a protein with a molecular mass that varies but is generally around 300 kDa. These fibers form intricate networks that are abundantly expressed in the extracellular matrix of several organs including the liver lymph nodes and bone marrow. Their unique structure permits a certain degree of flexibility and elasticity offering support to the surrounding cellular components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe structural framework provided by reticular fibers supports cellular organization in connective tissue environments. These fibers often associate with other extracellular matrix components such as glycoproteins and proteoglycans to form a complex that enhances the maintenance and resilience of connective tissue. They play an important role in filtering bodily fluids due to presence in lymphoid tissues like the spleen and lymph nodes where they aid in trapping particulates and pathogens.\u003cbr\u003e\nPathways\u003cbr\u003e\nType III collagen in reticular fibers functions within the complex processes of tissue organization and repair. Specifically they are part of the extracellular matrix pathway which includes interactions with other collagens and matrix metalloproteinases. Another related pathway is the wound healing pathway where type III collagen collaborates with fibronectin and type I collagen to facilitate tissue repair and regeneration.\u003cbr\u003e\nAlterations in reticular fiber networks associate with certain conditions such as liver fibrosis and Ehlers-Danlos syndrome. In liver fibrosis excessive reticular fiber deposition occurs leading to tissue stiffness due to increased type III collagen production. In Ehlers-Danlos syndrome mutations in the genes coding for collagen can disrupt reticular fiber function affecting tissue elasticity and strength. In both conditions changes in other collagens like type I collagen are often observed which further complicate the tissue integrity and contribute to disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843651784873,"sku":"ab150684","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab150684","provider":"Iright","version":"1.0","type":"link"}