{"product_id":"abcam-ab151416","title":"Abcam, ab151416, Anti-Noelin antibody - C-terminal","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Noelin antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OLFM1 aa 400 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human OLFM1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q99784\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe immunogen was raised from noelin isoform 1 precursor(NP_055094)\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNoelin also known as Olfactomedin 1 (OLFM1) is a secreted glycoprotein with a molecular mass around 55 kDa. It is expressed in the central nervous system particularly within the brain and retina and also in some peripheral tissues. The protein plays roles in synaptic function due to its ability to bind to components within the extracellular matrix.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNoelin contributes to the stabilization of synaptic structures and regulation of neuronal network formation. It interacts with other olfactomedin domain-containing proteins and forms complexes to mediate its functions. These interactions help maintain synaptic plasticity which is important for learning and memory processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe target takes part in neural development and function. It is involved in the Wnt signaling pathway important for cellular communication in brain development. Noelin also interacts with axon guidance molecules like netrins facilitating proper neuronal network formation. This places Noelin in important roles where fine-tuning synaptic connectivity is necessary.\u003cbr\u003e\nNoelin has connections to neurological conditions such as schizophrenia and neurodegenerative diseases. Alterations in Noelin expression or function can disrupt synaptic connectivity potentially leading to these disorders. The protein interacts with other proteins like DISC1 in schizophrenia highlighting its importance in maintaining mental health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854180110505,"sku":"ab151416","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab151416","provider":"Iright","version":"1.0","type":"link"}