{"product_id":"abcam-ab151584","title":"Abcam, ab151584, Anti-EXOSC8 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal EXOSC8 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EXOSC8 aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human EXOSC8 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96B26\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEXOSC8 also known as exosome component 8 forms part of the core of the exosome complex. This protein has a molecular weight of approximately 27 kDa. It is expressed in various tissues with enriched expression in bone marrow. EXOSC8 functions as an important structural component of the exosome complex aiding in the degradation and processing of RNA molecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEXOSC8 plays a central role in RNA metabolism as part of the exosome complex which is essential for RNA processing and turnover. It assists in the degradation of both precursor mRNA and aberrantly processed RNA. The exosome complex typically includes nine core components with EXOSC8 acting alongside these to help maintain RNA stability and facilitate gene expression regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nEXOSC8 is involved in RNA processing pathways essential for cellular function and survival. These pathways such as the RNA degradation pathway and mRNA surveillance pathway ensure the quality and regulation of RNA species. EXOSC8 interacts closely with other exosome components like EXOSC3 and EXOSC9 enhancing RNA degradation and contributing to cellular homeostasis.\u003cbr\u003e\nMutations in EXOSC8 link to neurological conditions notably pontocerebellar hypoplasia type 1B. This rare genetic disorder affects brain development and function leading to severe developmental delays. EXOSC8 mutations can disrupt normal exosome function impacting proteins like EXOSC3 which may worsen disease severity. Another disorder associated with EXOSC8 is autosomal recessive cerebellar ataxia where defective RNA processing contributes to the disease pathology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854233194665,"sku":"ab151584","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab151584","provider":"Iright","version":"1.0","type":"link"}