{"product_id":"abcam-ab152884","title":"Abcam, ab152884, Recombinant Human GST-1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human GST-1 protein is a Human Fragment protein, in the 168 to 267 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O43916,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as Carbohydrate sulfotransferase 1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGST-1 also known as Glutathione S-transferase 1 is an enzyme with a molecular mass of around 26 kDa. This target works mechanically by catalyzing the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. GST-1 shows expression in various tissues including the liver which is a major site for drug metabolism. It also plays a role in antioxidant defense helping to protect cells from damage by reactive oxygen species (ROS).\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWithin cellular contexts GST-1 performs critical functions related to the body's ability to handle oxidative stress. This enzyme does not typically operate as part of a larger complex but works individually or in collaboration with other GST isoenzymes. It contributes to the detoxification processes by neutralizing harmful compounds and maintaining cellular health. GST-1 also impacts the bioavailability and breakdown of hormones drugs and other xenobiotics.\u003cbr\u003e\nPathways\u003cbr\u003e\nGST-1 plays significant roles within oxidative stress response and detoxification pathways. It participates in the pathway that involves glutathione metabolism protecting cells from oxidative damage. GST-1 acts in conjunction with other antioxidant proteins like superoxide dismutase (SOD) and catalase working together to effectively minimize ROS levels. This cooperation helps maintain cellular homeostasis and prevents damage that can lead to various pathological conditions.\u003cbr\u003e\nGST-1 shows associations with cancer and neurodegenerative disorders. Alterations in GST-1 expression levels can influence the susceptibility to certain cancers including liver and lung cancers where detoxification capacity becomes compromised. In neurodegenerative disorders like Parkinson's disease GST-1 plays a protective role where its interaction with other GST isoenzymes could potentially affect neuronal survival. Understanding these connections helps in exploring therapeutic interventions for managing oxidative stress-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843882602665,"sku":"ab152884","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab152884","provider":"Iright","version":"1.0","type":"link"}