{"product_id":"abcam-ab154801","title":"Abcam, ab154801, Anti-PRP16 antibody [EPR9845]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PRP16 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9845,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPRP16 also known as RNA-dependent ATPase PRP16 is an essential component in pre-mRNA splicing. It functions mechanically as an ATP-dependent RNA helicase facilitating conformational changes in the spliceosome. This protein has a molecular mass of approximately 120 kDa. PRP16 expression occurs largely in the nucleus where it participates in RNA processing events.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPRP16 plays a critical role in the rearrangement of spliceosomal components during the second catalytic step of splicing. It is a part of the spliceosome complex and is necessary for the accurate removal of introns from pre-mRNA. This protein ensures the proper transition of the spliceosome from the C complex to the B* complex therefore influencing mRNA maturation and stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nPRP16 operates within the mRNA processing and splicing pathways. It is closely related to other spliceosomal proteins such as PRP8 and SF3B1 which coordinate to ensure efficient gene expression regulation through precise splicing events. These interconnected pathways highlight PRP16’s indispensable function in gene expression and RNA management.\u003cbr\u003e\nPRP16 exhibits a connection with genetic conditions involving splicing defects. Mutations or dysregulation of this helicase may relate to cancers or neurodegenerative diseases where splicing errors lead to aberrant protein products. PRP16's interactions with proteins like U2AF may provide additional insights into how its malfunction contributes to disease progression and pathology in such disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850218033321,"sku":"ab154801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab154801","provider":"Iright","version":"1.0","type":"link"}