{"product_id":"abcam-ab155604","title":"Abcam, ab155604, Anti-GRHPR antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GRHPR antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRHPR aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human GRHPR aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9UBQ7\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGRHPR also called glyoxylate reductase\/hydroxypyruvate reductase is an enzyme with mass about 35 kDa. It catalyzes the conversion of glyoxylate to glycolate and hydroxypyruvate to D-glycerate. This protein exists in the cytoplasm and is found in tissues like liver kidney and pancreas. Its enzymatic activity plays a role in regulating the balance between glyoxylate and glycolate within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGRHPR acts as a detoxifying agent by reducing glyoxylate levels protecting cells from glyoxylate-mediated toxicity. This enzyme is not part of a larger complex and functions independently. Well-balanced glyoxylate and glycolate levels are critical for cellular homeostasis and GRHPR ensures proper maintenance and regulation within metabolic pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nGRHPR participates in glyoxylate and dicarboxylate metabolism helping control the flow of metabolites. This involvement is significant in the context of the glyoxylate cycle and serine metabolism. Additionally it interacts with proteins such as lactate dehydrogenase during its activity within these metabolic pathways demonstrating its interconnectedness within cellular processes.\u003cbr\u003e\nGRHPR mutations are associated with primary hyperoxaluria type 2 a disorder characterized by excessive oxalate production leading to kidney stones. In this context GRHPR dysfunction can lead to increased glyoxylate levels causing elevated oxalate synthesis. The enzyme's connection to this disease is critical as it is one of the few proteins whose dysfunction directly results in the metabolic imbalance observed in primary hyperoxaluria type 2.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854398607529,"sku":"ab155604","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab155604","provider":"Iright","version":"1.0","type":"link"}