{"product_id":"abcam-ab158260","title":"Abcam, ab158260, Recombinant Human CYP51A1\/CYP51 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human CYP51A1\/CYP51 protein is a Human Fragment protein, in the 410 to 509 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q16850,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as CYP51A1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCYP51A1 also known as CYP51 is a cytochrome P450 enzyme. It plays an important mechanical role in cholesterol biosynthesis specifically catalyzing the demethylation of lanosterol. This enzyme has a molecular mass of approximately 55 kDa. CYP51A1 is expressed in multiple tissues including the liver testes and adrenal glands reflecting its widespread functional importance within the body.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCYP51A1 is essential in the production of sterols such as cholesterol which are fundamental components of cell membranes. It does not operate alone; rather it forms part of an enzymatic complex involved in lipid homeostasis. By participating in this complex CYP51A1 influences cell membrane integrity fluidity and signaling.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activity of CYP51A1 integrates into the cholesterol biosynthesis pathway where it serves a critical role in the downstream conversion of lanosterol to cholesterol. Its action influences the pathway alongside other key enzymes like HMG-CoA reductase. Additionally the enzyme participates in broader lipid metabolic pathways linking with proteins such as squalene synthase that also contribute to sterol production.\u003cbr\u003e\nCYP51A1's activity associates with certain lipid metabolism disorders including congenital adrenal hyperplasia and Smith-Lemli-Opitz syndrome. These conditions often involve disrupted cholesterol synthesis where CYP51A1’s malfunction can play a part. Moreover CYP51A1 connects to liver function through its interaction with proteins such as sterol regulatory element binding proteins (SREBPs) which regulate cholesterol homeostasis and can be associated with liver diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843927298217,"sku":"ab158260","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab158260","provider":"Iright","version":"1.0","type":"link"}