{"product_id":"abcam-ab158492","title":"Abcam, ab158492, Recombinant Human GALNS\/Chondroitinase protein","description":"\u003cp\u003eSize: 2µg\u003cbr\u003e\nRecombinant Human GALNS\/Chondroitinase protein is a Human Full Length protein, in the 1 to 522 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P34059,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as GALNS.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nChondroitinase also known as N-acetylgalactosamine-6-sulfatase (GALNS) is an enzyme involved in the degradation of glycosaminoglycans such as chondroitin sulfate and keratan sulfate. It is a lysosomal hydrolase enzyme that plays an important role in remodeling the extracellular matrix by cleaving sulfate groups from these molecules. The molecular mass of GALNS is approximately 60 kDa. GALNS expression primarily occurs in tissues like cartilage bones and connective tissues reflecting its function in skeletal development and maintenance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nN-acetylgalactosamine-6-sulfatase acts as a critical player in catabolism breaking down complex polysaccharides in lysosomes. By degrading glycosaminoglycans it prevents accumulation of excessive polysaccharides in cells which might lead to cellular dysfunction. GALNS operates as a single molecule not forming any known complexes yet its activity is integral to maintaining cellular homeostasis and preventing pathological buildup of substrates within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nGALNS functions in the glycosaminoglycan metabolism pathway essential for recycling cellular materials from the extracellular matrix. Another related pathway is the lysosomal degradation pathway where it relates to other enzymes like iduronate-2-sulfatase that also participate in the breakdown of complex molecules. These pathways collectively help in maintaining normal cellular function by facilitating the turnover of matrix components.\u003cbr\u003e\nN-acetylgalactosamine-6-sulfatase relates to Morquio A syndrome a lysosomal storage disorder caused by deficiencies in GALNS activity. This leads to abnormal accumulation of keratan sulfate and chondroitin sulfate resulting in skeletal abnormalities and growth issues. GALNS has also connections to mucopolysaccharidosis IV where defects in this enzyme similarly cause buildup of glycosaminoglycans. Proteins like N-sulfoglucosamine sulfohydrolase show association with GALNS through shared pathways in these disorders highlighting the interconnected nature of enzyme functions in lysosomal storage diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843977859241,"sku":"ab158492","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab158492","provider":"Iright","version":"1.0","type":"link"}