{"product_id":"abcam-ab159078","title":"Abcam, ab159078, Recombinant Human PDE9A protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PDE9A protein is a Human Full Length protein, in the 1 to 533 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O76083,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDE9A is a phosphodiesterase enzyme that breaks down cyclic guanosine monophosphate (cGMP) into non-cyclic GMP therefore regulating intracellular levels of cGMP. This enzyme has a molecular mass of approximately 65 kilodaltons. Researchers often refer to PDE9A also as phosphodiesterase 9A. It shows higher expression in the brain and heart with presence also noted in the kidneys and lungs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDE9A regulates the signaling processes by controlling cGMP turnover. It functions as a part of a larger network of proteins involved in intracellular signal transduction. PDE9A does not typically form distinct complexes but interacts with signaling components to maintain balanced cGMP concentrations which is essential for signaling related to vasodilation and platelet aggregation.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDE9A influences both cardiovascular and central nervous system pathways. In the cardiovascular system it interacts with nitric oxide signaling which has connections to blood pressure regulation through vasodilation. Within the CNS PDE9A is involved in synaptic plasticity relating to proteins like phosphodiesterase PDE5 and PDE2 which also handle cyclic nucleotide breakdown affecting neurotransmitter signaling and learning processes.\u003cbr\u003e\nPDE9A has connections to conditions like heart failure and Alzheimer’s disease. In heart failure PDE9A’s regulation of cGMP affects nitric oxide signaling and cardiac function. In Alzheimer’s disease its influence on synaptic plasticity through interactions with proteins like amyloid precursor protein (APP) suggests a role in cognitive decline making it a potential therapeutic target for modulating synaptic signaling and cognitive function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843971076265,"sku":"ab159078","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab159078","provider":"Iright","version":"1.0","type":"link"}