{"product_id":"abcam-ab159808","title":"Abcam, ab159808, Recombinant Human ZAN protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human ZAN protein is a Human Fragment protein, in the 19 to 113 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9Y493,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZAN also known as Zonadhesin is a sperm-specific protein involved in the binding of sperm to the egg's zona pellucida. It has a molecular mass of approximately 280 kDa. Zonadhesin's expression is primarily detected in the testis particularly in spermatogenic cells. This protein plays an essential role during fertilization by mediating the initial adherence of sperm to the egg surface which is an important step in the fertilization process.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein enables the gamete interaction necessary for successful reproduction. Zonadhesin functions by recognizing and binding to specific glycoproteins on the egg's zona pellucida. This interaction facilitates the penetration process allowing the sperm to deliver its genetic material into the egg. Zonadhesin operates alone and doesn’t join any known protein complex highlighting its autonomous action in gamete recognition.\u003cbr\u003e\nPathways\u003cbr\u003e\nZonadhesin's role in sperm-egg recognition directly implicates it in reproductive pathways particularly the acrosome reaction pathway which prepares the sperm for binding and penetrating the egg. It works in conjunction with acrosomal enzymes like acrosin which further facilitate the penetration of the zona pellucida. Zonadhesin's function in this pathway ensures that the sperm can navigate the zona pellucida barrier and engage in fertilization.\u003cbr\u003e\nAbnormalities in Zonadhesin expression or function may lead to fertility issues such as sperm incapacitation or male infertility. Dysfunction in this protein can disrupt sperm-zona pellucida interaction making successful fertilization challenging. In cases of infertility related to Zonadhesin there may be interest in the protein sperm antigen 17 (SP17) as it also plays a part in reproductive processes and imbalances or dysfunctions in either protein can contribute to reproductive disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843949809833,"sku":"ab159808","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab159808","provider":"Iright","version":"1.0","type":"link"}