{"product_id":"abcam-ab160886","title":"Abcam, ab160886, Recombinant Human ANGPTL7 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human ANGPTL7 protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O43827,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ANGPTL7 protein also known as Angiopoietin-like 7 plays a role in mechanistic processes. It has a molecular mass of about 45 kDa. ANGPTL7 is expressed primarily in the cornea and trabecular meshwork of the eye but it is also found in other tissues like the liver and heart. This protein is part of the larger angiopoietin-like protein family which is involved in numerous functions related to angiogenesis and metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANGPTL7 participates in the regulation of extracellular matrix composition and collagen deposition affecting tissue remodeling. It does not form a known complex with other molecules but influences the structural integrity of tissues through its regulatory actions. ANGPTL7 potentially interacts with cellular receptors to mediate these effects contributing to maintenance and repair of tissue structures.\u003cbr\u003e\nPathways\u003cbr\u003e\nANGPTL7 interacts within the framework of the TGF-beta signaling pathway influencing cellular growth and differentiation. Another important pathway involving ANGPTL7 is the Wnt signaling cascade which is important for various developmental processes. In these pathways ANGPTL7 has functional interactions with proteins such as TGF-beta and beta-catenin modulating their activity and impact on cellular functions.\u003cbr\u003e\nANGPTL7 has connections to ocular diseases like glaucoma where its expression levels alter the outflow facility of aqueous humor. It also relates to fibrosis since the regulation of collagen deposition is an important factor. The involvement of ANGPTL7 in these conditions links it with proteins such as myocilin in glaucoma and TIMP-1 in fibrosis highlighting its role in pathological tissue remodeling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843995095209,"sku":"ab160886","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab160886","provider":"Iright","version":"1.0","type":"link"}