{"product_id":"abcam-ab161312","title":"Abcam, ab161312, Recombinant Human SLC7A9 protein","description":"\u003cp\u003eSize: 2µg\u003cbr\u003e\nRecombinant Human SLC7A9 protein is a Human Full Length protein, in the 1 to 487 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P82251,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC7A9 also known as b(0+)-type amino acid transporter 1 (rBAT) functions as a sodium-independent transporter responsible for the uptake of neutral and basic amino acids. It has a molecular weight of approximately 52 kDa. This transporter is expressed largely in the kidney and small intestine where it plays an important role in amino acid reabsorption. SLC7A9 is part of the solute carrier family 7 which is involved in transporting amino acids across cellular membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSLC7A9 facilitates the selective transepithelial transport of amino acids through its association with the heavy chain rBAT forming a functional heteromeric complex. This complex ensures effective transport of specific amino acids particularly cystine and dibasic amino acids from the lumen into epithelial cells which is critical for preventing loss of these amino acids in urine. This biological role is integral to maintaining amino acid levels and systemic nitrogen economy highlighting its importance in everyday metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLC7A9 activity interacts notably within the cystine and arginine metabolism pathways. Here its transporter function complements the action of other solute carriers and enzymes like SLC3A1 its associated partner in the heterodimeric complex to modulate amino acid concentrations within systemic circulation. SLC7A9 also influences the lysine degradation pathway which involves the cellular regulation of lysine levels interplaying with enzymes such as lysine-ketoglutarate reductase to maintain metabolic homeostasis.\u003cbr\u003e\nSLC7A9 mutations have a significant association with the condition cystinuria a disorder characterized by the excessive excretion of cystine leading to kidney stone formation. Variants of SLC7A9 alter amino acid transport capacity impacting cystine stone formation and accumulation. Similarly disruptions in SLC7A9 function correlate with lysinuric protein intolerance a metabolic disorder linked to impaired lysine metabolism where it shares dysfunction with related protein SLC3A1. Both conditions highlight the importance of SLC7A9 in maintaining amino acid balance and renal health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843944599721,"sku":"ab161312","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab161312","provider":"Iright","version":"1.0","type":"link"}