{"product_id":"abcam-ab162304","title":"Abcam, ab162304, Recombinant Human PILRA protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PILRA protein is a Human Full Length protein, in the 1 to 226 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9UKJ1,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPILRA also known as Paired immunoglobulin-like type 2 receptor alpha is a protein with a mass of about 38 kDa. It belongs to the immunoglobulin superfamily and acts as an inhibitory receptor. PILRA is expressed mainly in human tissues such as monocytes macrophages and certain subsets of dendritic cells. It interacts with ligands through its extracellular domain and transmits inhibitory signals via its cytoplasmic tail that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs).\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPILRA plays a significant role in the immune system regulation by inhibiting cellular activation processes. This regulation occurs through its participation in receptor-ligand interactions that modulate the immune response. It is not part of a complex but its pair PILRB acts as an activating receptor providing a balanced modulation of immune signaling. The balance between PILRA and PILRB affects how immune cells respond to various signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nPILRA is centrally involved in immune response pathways especially those controlling immune cell signaling. It interacts with proteins involved in immune system pathways such as LILRB1 which also mediates inhibitory signaling. PILRA functions in signaling pathways to regulate the activation and inhibition of immune responses maintaining immune system homeostasis.\u003cbr\u003e\nPILRA associates with alterations in immune response mechanisms that can lead to autoimmune diseases and infections. Research links PILRA to diseases such as multiple sclerosis and certain viral infections. In these conditions PILRA's role in immune signaling modulation becomes important as it coordinates with proteins like PILRB to affect the immune system's response to different pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843992866985,"sku":"ab162304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab162304","provider":"Iright","version":"1.0","type":"link"}