{"product_id":"abcam-ab16287","title":"Abcam, ab16287, Anti-SSEA4 antibody [MC813-70]","description":"\u003cp\u003eSize: 20µL-TRIAL \/ 200µL\u003cbr\u003e\nAnti-SSEA4 antibody [MC813-70] (ab16287) is a mouse monoclonal antibody detecting SSEA4 in  Flow Cytometry, ICC\/IF . Suitable for  Human . - Over 180 publications - Trusted since 2006\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MC813-70,\u003cbr\u003e\nIsotype:IgG3,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-SSEA4 antibody [MC813-70] (ab16287) is a mouse monoclonal antibody and is validated for use in Flow Cytometry (Flow Cyt), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-SSEA4 [MC813-70] (ab16287) was first used in a scientific publication in 2006 and has been cited over 180 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-SSEA4 [MC813-70] (ab16287) has over 10 independent reviews from customers.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Purification notes-Tissue culture supernatant was cross flow concentrated., Storage buffer-Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSSEA4 known as Stage-Specific Embryonic Antigen-4 is a glycolipid antigen involved in various cellular processes. It has a molecular mass of approximately 868.6 Da. SSEA4 is mainly expressed on the surface of pluripotent stem cells including embryonic stem cells and induced pluripotent stem cells. Additionally it can be found in germ cells and certain cancer cells serving as an important marker for these cell types.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSSEA4 plays a critical role in the identity and maintenance of pluripotency in stem cells. As a component of the glycosphingolipid complex it is involved in cell signaling pathways that regulate cell differentiation and self-renewal. The presence of SSEA4 on cell surfaces helps in identifying pluripotent stem cells facilitating research and applications in regenerative medicine.\u003cbr\u003e\nPathways\u003cbr\u003e\nSSEA4 influences several key cellular processes related to pluripotency and differentiation. It integrates prominently in the Wnt signaling pathway and the PI3K\/Akt pathway which are essential for maintaining stem cell pluripotency and promoting survival. Interactions with proteins such as Β-catenin in the Wnt pathway help modulate transcription factors critical for pluripotency.\u003cbr\u003e\nSSEA4 expression associates with certain cancers particularly in germ cell tumors and some neuroblastomas. In cancer research it interacts with other surface antigens such as CD133 influencing tumor-initiating cell populations. The presence of SSEA4 in these cells can indicate aggressive tumor phenotypes and potential targets for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855764639913,"sku":"ab16287","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab16287","provider":"Iright","version":"1.0","type":"link"}