{"product_id":"abcam-ab16434","title":"Abcam, ab16434, Anti-Desmoplakin I+II antibody [DP2.15]","description":"\u003cp\u003eSize: 25µg\u003cbr\u003e\nMouse Monoclonal DESP antibody. Suitable for ICC, WB, ICC\/IF, IHC-Fr and reacts with Mouse, Rat, Chicken, Human, Cow samples. Cited in 36 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:DP2.15,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Chicken, Cow, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, ICC, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:The clone number has been updated from (2Q400) to (DP2.15) both clone numbers name the same antibody clone.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSuitable for use in the detection of primary and metastatic carcinomas.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Add glycerol to a final volume of 50% for extra stability and aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDesmoplakin is a critical component of the cell structure acting as a link between desmosomes and the intermediate filament network. It exists in two isoforms Desmoplakin I and Desmoplakin II with molecular masses of approximately 332 kDa and 260 kDa respectively. Desmoplakin is mainly expressed in tissues with high mechanical stress such as the heart and skin where strong cell adhesion is necessary. Alternate names like Desmoplakine may also be used in some scientific literature.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDesmoplakin is essential for maintaining cell adhesion and structural integrity within tissues. It serves as part of the desmosomal complex where it anchors intermediate filaments to the desmosomal plaque ensuring the mechanical stability required by tissues under mechanical stress. This function is particularly critical in epithelial cells and cardiac tissue where desmoplakin interacts closely with other desmosomal components to maintain robust cell-to-cell connections.\u003cbr\u003e\nPathways\u003cbr\u003e\nDesmoplakin plays a significant role in the regulation of adhesive structures through its involvement in the intercellular junctional complex pathways. The protein collaborates with other key components of these pathways such as plakoglobin and plakophilins. Its role in these pathways ensures that cell adhesion and stability are maintained across different tissue types which is vital for normal cellular function and organization.\u003cbr\u003e\nMutations or dysfunctional interactions of desmoplakin can lead to conditions like arrhythmogenic right ventricular cardiomyopathy (ARVC) and skin disorders such as epidermolysis bullosa simplex. In ARVC desmoplakin-related defects may disrupt interactions with other desmosomal proteins like plakoglobin impacting heart muscle integrity and function. Similarly in epidermolysis bullosa simplex altered desmoplakin function compromises skin cell adhesion leading to increased susceptibility to injury.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860508463273,"sku":"ab16434","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab16434","provider":"Iright","version":"1.0","type":"link"}