{"product_id":"abcam-ab166905","title":"Abcam, ab166905, Anti-TTC14 antibody [EPR11143]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TTC14 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11143,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTTC14 also known as tetratricopeptide repeat domain 14 is a protein with a molecular mass around 68 kDa. This protein plays an important mechanical role in cilia function by possessing tetratricopeptide repeat domains that facilitate protein-protein interactions necessary for its activity. TTC14 shows expression predominantly within tissues that require motile cilia like respiratory epithelium and reproductive tracts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTTC14 is involved in the functioning and maintenance of ciliary structures essential for cellular motility and fluid movement across various surfaces. TTC14 acts as a part of the ciliary transition zone a critical component that regulates ciliary protein import and function. This involvement implies a significant role in modifying the composition of ciliary membrane essential for its sensing and motility purposes.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers place TTC14 within ciliary assembly and maintenance pathways which involve coordination and transport mechanisms that ensure proper cilium structure and function. It also associates with the intraflagellar transport system working alongside proteins like IFT88 and IFT20 to sustain ciliary activities. Such participation indicates TTC14’s importance in maintaining ciliary integrity and function.\u003cbr\u003e\nMalfunction or mutations in TTC14 can lead to conditions associated with ciliary dysfunction like Primary Ciliary Dyskinesia (PCD) and infertility due to impaired sperm motility. TTC14 shows interaction with other key ciliary-related proteins such as DNAH5 where abnormalities typically result in overlapping ciliary disorders. Consequently studying TTC14 contributes to understanding the molecular mechanisms underpinning these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850444918953,"sku":"ab166905","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab166905","provider":"Iright","version":"1.0","type":"link"}