{"product_id":"abcam-ab167199","title":"Abcam, ab167199, Anti-MCJ antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal MCJ antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DNAJC15.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human DNAJC15.Q9Y5T4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMCJ also known as DNAJC15 is a mitochondrial protein with an approximate mass of 17 kDa. It serves various functions via its presence in different tissues including the liver and muscle. MCJ belongs to the J-protein family and it regulates protein folding and mitochondrial function. Structurally MCJ acts as a co-chaperone and influences mitochondrial respiration by inhibiting the mitochondrial respiratory chain complex I.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of MCJ extends beyond its mechanical actions. The protein participates in an intricate process that affects the cell's metabolism and energy production. MCJ often functions as part of a complex involving several mitochondrial proteins. It regulates mitochondrial energy production by inhibiting the activity of respiratory chain complexes leading to a direct impact on ATP synthesis and cellular metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nMCJ influences mitochondrial bioenergetics and oxidative stress pathways. It is intertwined with the mitochondrial respiratory chain pathway where it modulates the activity of complex I thereby affecting energy production and cell survival. MCJ interacts with other proteins such as NDUFA9 a component of complex I and plays a role in maintaining mitochondrial efficiency and reducing oxidative damage under stress conditions.\u003cbr\u003e\nMCJ is associated with cancer and metabolic syndrome. Decreased expression of MCJ has been linked with various cancers due to its impact on cell survival and proliferation. In metabolic disorders alterations in MCJ expression affect energy metabolism and insulin sensitivity. Related proteins like the anti-apoptotic Bcl-2 family can further connect MCJ to these conditions illustrating the protein’s influence on disease-related mitochondrial dysfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852264394921,"sku":"ab167199","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab167199","provider":"Iright","version":"1.0","type":"link"}