{"product_id":"abcam-ab167278","title":"Abcam, ab167278, Anti-FBXO7 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal FBXO7 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FBXO7.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human FBXO7.Q9Y3I1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBXO7 also known as F-box only protein 7 is part of the F-box protein family. This protein plays a role in the ubiquitin-proteasome pathway where it functions as a part of the SCF (Skp Cullin F-box containing) complex. Its molecular mass is roughly 74 kDa. FBXO7 expression is found in various tissues with significant expression in the brain. The SCF complex is important for regulating protein degradation where FBXO7 acts to recruit substrates for ubiquitination and subsequent proteasomal degradation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBXO7 is involved in regulating cell cycle and mitosis by tagging specific proteins for degradation. It forms a part of cellular complexes that impact pathways controlling apoptosis and cellular proliferation. FBXO7 interacts with proteins such as CDK6 important for cell cycle regulation allowing it to influence the progression of the cell cycle phases. Its role in balancing cell survival and death connects it to broader cellular functions essential for maintaining homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nFBXO7 integrates into the ubiquitin-proteasome degradation and cell cycle regulation pathways. It affects the ubiquitination and degradation of cyclin D through its interaction with CDK6. Moreover FBXO7 involves itself in the mitochondrial quality control pathway interacting with PINK1 a protein integral to this process. These interactions highlight FBXO7’s significance in modulating cellular function and response to stress.\u003cbr\u003e\nFBXO7 has links to Parkinson's disease and certain cancers. Mutations in the FBXO7 gene lead to disruptions in its function which correlates with early-onset Parkinsonism. Interactions with PARKIN through the PINK1 pathway emphasize its role in neuronal maintenance and survival. In cancer FBXO7 can affect tumor progression where its dysregulation impacts cell cycle and apoptotic pathways. Understanding FBXO7 interactions can assist in developing therapeutic strategies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852269932713,"sku":"ab167278","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab167278","provider":"Iright","version":"1.0","type":"link"}