{"product_id":"abcam-ab167899","title":"Abcam, ab167899, Recombinant Human ECRG-2 protein","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRecombinant Human ECRG-2 protein is a Human Full Length protein, in the 20 to 85 aa range, expressed in Escherichia coli, with \u0026gt;85%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;85% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P58062,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 40% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPreviously labelled as SPINK7.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEpithelial cell-related gene 2 commonly known as ECRG-2 is a protein involved in several cellular processes. The protein has a molecular mass of about 8 kDa. Researchers have found it expressed mainly in the epithelium especially in esophageal tissues but it also appears in several other tissue types. ECRG-2 plays a role in cell differentiation proliferation and apoptosis meaning it has an important function in maintaining healthy cell behavior and tissue development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nECRG-2 influences gene expression and impacts cellular responses to stress and injury. It functions as a tumor suppressor and has shown activity inhibiting proliferation of cancer cells. ECRG-2 is not part of any known complex but interacts with various other proteins supporting its suppressor functions. This interaction helps it to regulate cell cycle and protect cells from malignant transformations.\u003cbr\u003e\nPathways\u003cbr\u003e\nECRG-2 influences several molecular pathways including the p53 pathway. p53 is a critical pathway in cell cycle regulation and apoptosis. ECRG-2 interacts with proteins involved in this pathway reinforcing the prevention of tumor development. Additionally it connects indirectly to pathways involving NF-κB which is important for immune response and inflammation and shares functions with ECRG-2 in regulating cellular growth and apoptosis.\u003cbr\u003e\nECRG-2 has been linked to esophageal cancer and gastric cancer. Research suggests reduced expression of ECRG-2 correlates with tumor growth and metastasis. In these cancers it frequently interacts with proteins like p53 and alterations in these interactions can further disease progression. Understanding ECRG-2's role in these conditions assists in developing potential therapeutic strategies that target the molecular pathways associated with these cancers.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843803271337,"sku":"ab167899","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab167899","provider":"Iright","version":"1.0","type":"link"}