{"product_id":"abcam-ab168532","title":"Abcam, ab168532, Anti-WDR45 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal WDR45 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human WDR45.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human WDR45.Q9Y484\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe WDR45 protein also known as WD repeat domain phosphoinositide-interacting protein 4 (WIPI4) plays a necessary role in the autophagic process. It is a protein of approximately 42 kDa and consists of seven WD40 repeats which facilitate protein-protein interactions. The protein is broadly expressed in various tissues particularly in the brain. These interactions are critical in autophagy a process for degrading and recycling cellular components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWDR45 contributes significantly to the regulation of autophagy. It acts as part of a multi-protein complex referred to as the autophagy-related 2 (ATG) complex. This complex is involved in autophagosome formation which is an important component in cellular degradation pathways. WDR45 binds phosphoinositides which are phospholipids integral to vesicle trafficking and membrane dynamics during autophagy.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe influence of WDR45 is evident in the PI3K\/Akt signaling and AMPK signaling pathways. These pathways regulate cellular energy homeostasis and the response to metabolic stress. PI3K\/Akt and AMPK modulate the activity of the mTOR pathway which is known to suppress autophagy. WDR45 interacts with other autophagy-related proteins such as LC3 and ULK1 facilitating the initiation of the autophagic process.\u003cbr\u003e\nThe connection to WDR45 is pronounced in neurodegenerative diseases like beta-propeller protein-associated neurodegeneration (BPAN) and Parkinson's disease. Mutations in WDR45 lead to defective autophagy resulting in the accumulation of damaged organelles and proteins in neurons. It is linked to proteins involved in these disorders such as PINK1 and Parkin further highlighting its potential role in disease pathology through impaired mitochondrial quality control and neural damage.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848521568425,"sku":"ab168532","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab168532","provider":"Iright","version":"1.0","type":"link"}