{"product_id":"abcam-ab169273","title":"Abcam, ab169273, Anti-ANKFY1 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal ANKFY1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ANKFY1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human ANKFY1.Q9P2R3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nANKFY1 also known as Ankyrin Repeat and FYVE Domain Containing 1 is a protein with a molecular mass of approximately 152 kDa. It plays a mechanical role in cellular processes by interacting with endosomal membranes through its FYVE domain which binds phosphatidylinositol 3-phosphate (PI3P). ANKFY1 is expressed in various tissues with notable expression in the brain highlighting its significance in neurological functions. The protein structure of ANKFY1 includes ankyrin repeats which facilitate protein-protein interactions and contribute to its function in cellular signaling and membrane trafficking.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANKFY1 regulates endosome dynamics and membrane trafficking. It does not usually form part of large protein complexes which allows it to efficiently interact with specific partners. Through its FYVE domain ANKFY1 participates in binding and trafficking of PI3P-enriched vesicles contributing to the maintenance of endosomal pathways. This interaction supports the sorting and distribution of cargo within cells impacting processes like receptor downregulation nutrient transport and signal transduction.\u003cbr\u003e\nPathways\u003cbr\u003e\nVarious cellular processes depend on ANKFY1's function in endosomal sorting. It is involved in the phosphatidylinositol signaling pathway affecting how cells interpret various extracellular cues. ANKFY1 also participates in the regulation of the endocytic pathway influencing the internalization and recycling of membrane receptors alongside proteins such as Rab GTPases. These pathways ensure that cellular responses are finely tuned by controlling the localization and activity of various signaling molecules.\u003cbr\u003e\nStudies link ANKFY1 to certain neurological conditions including Alzheimer's disease. ANKFY1's role in endosomal trafficking can influence amyloid precursor protein (APP) processing thereby impacting the production of amyloid-beta peptides in Alzheimer's pathology. Additionally ANKFY1 is connected to disorders of cognitive function where its interaction with signaling pathways involving synaptic proteins may play a part. These connections highlight the potential importance of ANKFY1 in maintaining neuronal health and function marking it as a point of interest in understanding neurodegenerative diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852262789289,"sku":"ab169273","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab169273","provider":"Iright","version":"1.0","type":"link"}