{"product_id":"abcam-ab169287","title":"Abcam, ab169287, Anti-Golgin 97 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal Golgin 97 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GOLGA1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human GOLGA1.Q92805\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGolgin-97 also known as Golgin subfamily A member 1 is a protein that plays a significant role in the Golgi apparatus function. This protein has a molecular mass of approximately 97 kDa. Golgin-97 is widely expressed in the Golgi apparatus of eukaryotic cells. Its structure facilitates its function as a membrane-bound protein influencing the organization of the Golgi stack and maintenance of the Golgi ribbon.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGolgin-97 participates in tethering of transport vesicles to the Golgi membrane ensuring efficient trafficking of proteins to their correct destinations. It is part of the golgin family which includes several coiled-coil proteins critical for Golgi structure and dynamics. Golgin-97 acts within a larger protein complex that interacts with other Golgi-associated proteins to regulate vesicle docking and fusion.\u003cbr\u003e\nPathways\u003cbr\u003e\nProtein and lipid trafficking involve Golgin-97 significantly as it aids in vesicular transport coordination from the endoplasmic reticulum to the Golgi and within the Golgi stacks. The protein interacts closely with Rab GTPases a class of proteins that regulate vesicle movement. Golgin-97's function intertwines with pathways like the secretory pathway and the endocytic pathway linking it to other proteins such as Rab6 and Rab9.\u003cbr\u003e\nGolgin-97 has associations with pathologies involving Golgi dysfunction and transport defects. For instance it relates to diseases like neurodegenerative disorders where proper protein trafficking is disrupted. The malfunction of Golgin-97 can affect proteins like Alzheimer's disease proteins as vesicular transport failure can lead to their mislocalization or aggregation contributing to disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852263772329,"sku":"ab169287","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab169287","provider":"Iright","version":"1.0","type":"link"}