{"product_id":"abcam-ab169548","title":"Abcam, ab169548, Anti-NRK1 antibody [EPR11190]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NRK1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11190,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNRK1 also known as nicotinamide riboside kinase 1 is an enzyme involved in the NAD+ biosynthesis pathway. It functions by phosphorylating nicotinamide riboside (NR) to generate nicotinamide mononucleotide (NMN) an important precursor for NAD+ synthesis. The molecular mass of NRK1 is approximately 34 kDa. This protein is expressed in various tissues including liver brain and muscle where it contributes to the regulation of cellular NAD+ levels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays an important role in cellular energy metabolism and regulation. NRK1 is not part of a larger complex but interacts directly with its substrate nicotinamide riboside. By catalyzing the conversion of NR to NMN NRK1 supports the maintenance of NAD+ levels inside cells which is essential for numerous metabolic processes including those related to energy production and cellular stress responses. NRK1 activity helps regulate critical cellular functions such as DNA repair and mitochondrial function.\u003cbr\u003e\nPathways\u003cbr\u003e\nNicotinamide riboside kinase 1 integrates into the NAD+ biosynthesis pathway. This pathway is important for maintaining adequate NAD+ levels necessary for various enzymes like sirtuins and poly(ADP-ribose) polymerases (PARPs) that rely on NAD+ as a co-factor. The NRK1-mediated conversion process is closely related to other key proteins such as NRK2 which shares similar enzymatic activity and roles in NAD+ metabolism. Together these proteins contribute to the cellular mechanisms that control energy metabolism and stress responses.\u003cbr\u003e\nNicotinamide riboside kinase 1 has shown relevance to metabolic disorders such as obesity and diabetes. Dysregulation of NAD+ metabolism partly attributed to altered NRK1 activity can influence the onset and progression of these conditions. Additionally the role of NRK1 in supporting healthy NAD+ levels connects it to proteins like SIRT1 which mediates beneficial effects on metabolism and longevity. Understanding NRK1's involvement in these pathways may advance therapeutic strategies for metabolic and age-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850226225321,"sku":"ab169548","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab169548","provider":"Iright","version":"1.0","type":"link"}