{"product_id":"abcam-ab169604","title":"Abcam, ab169604, Anti-B4GALT4 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal B4GALT4 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human B4GALT4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human B4GALT4.O60513\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe B4GALT4 protein also known as beta-14-galactosyltransferase 4 participates in the addition of galactose to poly-N-acetyllactosaminoglycan structures found on glycans. This enzymatic activity occurs primarily in the Golgi apparatus where B4GALT4 modifies glycoproteins and glycolipids. It has a molecular mass of approximately 45 kDa. Expression of this protein happens across various tissues including the liver kidney and brain indicating its involvement in diverse biological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nB4GALT4 helps in carbohydrate metabolism by acting as part of a complex. It plays an important role in regulating cell-cell recognition and signaling. Its activity affects the composition of glycoconjugates involved in immune responses and cellular interactions. The protein is essential in forming N-glycans which are critical components for extracellular matrix organization and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nB4GALT4 features prominently in the glycosylation pathway. It influences the biosynthesis of glycoproteins and other related molecules. In the context of glycosylation B4GALT4 works alongside other glycosyltransferases like B3GALT6 and contributes to essential pathways such as the galactose metabolism. These pathways are vital for generating complex glycans necessary for various cellular functions.\u003cbr\u003e\nAberrations in B4GALT4 activity associate with certain congenital disorders of glycosylation (CDG) and some cancers. In CDG mutations impacting this protein cause improper glycan structures leading to multisystemic disease symptoms. Cancers sometimes show altered expression or activity of glycosyltransferases including B4GALT4 affecting cell behavior and tumor progression. The protein’s interaction with components such as B3GALT6 in these conditions highlights its importance in maintaining cellular homeostasis and normal physiological function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852267245737,"sku":"ab169604","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab169604","provider":"Iright","version":"1.0","type":"link"}